State Street
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State Street’s Tyra Biosciences TYRA Stock Holding History

State Street’s Portfolio TYRA Stock Details TYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$46.6M Buy
1,216,078
+466,615
+62% +$15.1M ﹤0.01% 1780
2025
Q4 		$19.7M Buy
749,463
+320,991
+75% +$5.9M ﹤0.01% 2285
2025
Q3 		$5.99M Buy
428,472
+9,488
+2% +$108K ﹤0.01% 2926
2025
Q2 		$4.01M Buy
418,984
+4,996
+1% +$47.5K ﹤0.01% 3037
2025
Q1 		$3.85M Buy
413,988
+6,415
+2% +$83K ﹤0.01% 2983
2024
Q4 		$5.67M Buy
407,573
+22,841
+6% +$415K ﹤0.01% 2913
2024
Q3 		$9.05M Buy
384,732
+16,248
+4% +$341K ﹤0.01% 2667
2024
Q2 		$5.89M Buy
368,484
+76,250
+26% +$1.31M ﹤0.01% 2846
2024
Q1 		$4.79M Buy
292,234
+26,880
+10% +$441K ﹤0.01% 2940
2023
Q4 		$3.68M Buy
265,354
+5,896
+2% +$76.3K ﹤0.01% 3091
2023
Q3 		$3.57M Buy
259,458
+3,081
+1% +$45.7K ﹤0.01% 3084
2023
Q2 		$4.37M Buy
256,377
+24,288
+10% +$352K ﹤0.01% 3059
2023
Q1 		$3.73M Buy
232,089
+15,463
+7% +$184K ﹤0.01% 3102
2022
Q4 		$1.65M Sell
216,626
-1,362
-0.6% -$9.63K ﹤0.01% 3435
2022
Q3 		$1.92M Buy
217,988
+3,963
+2% +$36.2K ﹤0.01% 3426
2022
Q2 		$1.53M Buy
214,025
+10,345
+5% +$82.4K ﹤0.01% 3539
2022
Q1 		$2.18M Buy
203,680
+72,670
+55% +$863K ﹤0.01% 3533
2021
Q4 		$1.84M Buy
+131,010
New +$2.6M ﹤0.01% 3662

Other funds holding TYRA

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
APMC
Alta Partners Management Company Jackson, Wyoming $151M AUM 296.21% 1-Year Est. Return
FCM
Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

State Street's TYRA Position: Q1 2026 in Review

State Street increased its Tyra Biosciences (TYRA) stake by 62% in Q1 2026, buying an estimated $15.1M and bringing the position to 1,216,078 shares worth $46.6M. The position accounts for ﹤0.01% of the portfolio, ranked #1780.

State Street first reported a position in TYRA in Q4 2021 and has held it in 18 quarters since. 164 funds tracked by Wall St. Rank hold TYRA as of Q1 2026.

  • State Street held 1,216,078 shares of Tyra Biosciences worth $46.6M as of Q1 2026.
  • State Street bought 466,615 Tyra Biosciences shares in Q1 2026, an estimated $15.1M.
  • Tyra Biosciences made up ﹤0.01% of State Street's portfolio in Q1 2026, its #1780 holding.
  • State Street first reported a position in Tyra Biosciences in Q4 2021 and has held it in 18 quarters since.
  • 164 funds tracked by Wall St. Rank held Tyra Biosciences as of Q1 2026.

Based on State Street's 13F filing for Q1 2026, filed 15 May 2026.