Sio Capital Management’s Aprea Therapeutics APRE Stock Holding History

Sio Capital Management’s Portfolio APRE Stock Details APRE Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-112,223	Closed	-$166K	–	69
2025 Q3	$166K	Sell	112,223 -167,146	-60%	-$275K	0.04%	47
2025 Q2	$472K	Buy	279,369 +2,766	+1%	+$4.71K	0.18%	43
2025 Q1	$564K	Hold	276,603	–	–	0.17%	46
2024 Q4	$910K	Hold	276,603	–	–	0.26%	39
2024 Q3	$761K	Hold	276,603	–	–	0.3%	28
2024 Q2	$1.13M	Hold	276,603	–	–	0.3%	37
2024 Q1	$1.85M	Sell	276,603 -3,397	-1%	-$21.1K	0.55%	38
2023 Q4	$1.32M	Hold	280,000	–	–	0.3%	29
2023 Q3	$1.17M	Hold	280,000	–	–	0.36%	35
2023 Q2	$882K	Hold	280,000	–	–	0.22%	35
2023 Q1	$1.24M	Buy	+280,000	New	+$2.07M	0.61%	27

Other funds holding APRE

ACM

AIGH Capital Management Baltimore, Maryland $733M AUM 327.32% 1-Year Est. Return

Murchinson Toronto, Ontario, Canada $791M AUM 68.08% 1-Year Est. Return

SFM

Sphera Funds Management Tel Aviv, Israel $630M AUM 108.65% 1-Year Est. Return

NCM

Nantahala Capital Management New Canaan, Connecticut $2.72B AUM 121.58% 1-Year Est. Return

DRW Securities Chicago, Illinois $7.21B AUM 20.54% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return

Jane Street New York $777B AUM 61.18% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

Sio Capital Management's APRE Position: Q4 2025 in Review

Sio Capital Management sold out of Aprea Therapeutics (APRE) in Q4 2025, closing a stake of 112,223 shares — an estimated $166K sold.

Sio Capital Management first reported a position in APRE in Q1 2023 and held it in 11 quarters. The position peaked at $1.85M in Q1 2024. 22 funds tracked by Wall St. Rank hold APRE as of Q4 2025.

Sio Capital Management reported no remaining Aprea Therapeutics position as of Q4 2025 after selling out during the quarter.
Sio Capital Management sold 112,223 Aprea Therapeutics shares in Q4 2025, an estimated $166K.
Sio Capital Management first reported a position in Aprea Therapeutics in Q1 2023 and held it in 11 quarters.
Sio Capital Management's Aprea Therapeutics position peaked at $1.85M in Q1 2024.
22 funds tracked by Wall St. Rank held Aprea Therapeutics as of Q4 2025.

Based on Sio Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.