We are live on ! Find out more
SCM

Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+18.21%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$636M
AUM Growth
+$241M
Cap. Flow
+$141M
Cap. Flow %
22.24%
Top 10 Hldgs %
53.71%
Holding
77
New
26
Increased
8
Reduced
17
Closed
9

Top Buys

Rank Stock Value
1
CI icon
Cigna
CI
+$48.3M
2
ZBH icon
Zimmer Biomet
ZBH
+$36.6M
3
OGN icon
Organon & Co
OGN
+$27M
4
ICLR icon
Icon
ICLR
+$22.7M
5
WAY
Waystar Holding Corp
WAY
+$21.9M

Top Sells

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$25.4M
2
IRON icon
Disc Medicine
IRON
+$19.2M
3
ALKS icon
Alkermes
ALKS
+$17.4M
4
MRK icon
Merck
MRK
+$14.9M
5
HSIC icon
Henry Schein
HSIC
+$14.5M

Sector Composition

Rank Sector Weight
1 Healthcare 84.1%
2 Industrials 6.79%
3 Miscellaneous 5.13%
4 Consumer Staples 3.98%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CELC icon
1
Celcuity
CELC
$4.33B
$47.6M 7.48%
477,067
-309,459
-39% -$25.4M
CI icon
2
Cigna
CI
$73.7B
$47.4M 7.46%
+172,203
New +$48.3M
SNY icon
3
Sanofi
SNY
$107B
$47.1M 7.41%
971,686
+408,983
+73% +$20.3M
MMS icon
4
Maximus
MMS
$3.13B
$43.2M 6.79%
500,304
-57,311
-10% -$4.9M
ZBH icon
5
Zimmer Biomet
ZBH
$19.2B
$34.7M 5.45%
+385,642
New +$36.6M
RYTM icon
6
PUT
Rhythm Pharmaceuticals
RYTM
$7.38B
$28.4M 4.47%
+265,700
New +$28.2M
KVUE icon
7
Kenvue
KVUE
$36.8B
$25.3M 3.98%
1,465,442
+621,442
+74% +$10.2M
OGN icon
8
Organon & Co
OGN
$3.61B
$24.5M 3.86%
+3,421,765
New +$27M
ICLR icon
9
Icon
ICLR
$13.1B
$23.2M 3.65%
+127,202
New +$22.7M
WAY
10
Waystar Holding Corp
WAY
$5.03B
$20.1M 3.16%
+613,725
New +$21.9M
LIVN icon
11
LivaNova
LIVN
$4.43B
$19.8M 3.12%
+322,382
New +$18.4M
DNTH icon
12
Dianthus Therapeutics
DNTH
$5.92B
$19.6M 3.08%
474,503
-103,247
-18% -$4M
BHVN icon
13
Biohaven
BHVN
$2.33B
$14.1M 2.21%
+1,244,764
New +$15.4M
GPCR icon
14
Structure Therapeutics
GPCR
$3.38B
$14M 2.2%
+201,500
New +$8.23M
BMRN icon
15
BioMarin Pharmaceuticals
BMRN
$12.5B
$13.8M 2.18%
232,688
+7,574
+3% +$412K
TYRA icon
16
Tyra Biosciences
TYRA
$1.49B
$13.8M 2.18%
526,002
+11,055
+2% +$203K
BTSG icon
17
BrightSpring Health Services
BTSG
$11.7B
$11.5M 1.81%
+308,010
New +$10.3M
CNC icon
18
Centene
CNC
$32B
$11.3M 1.78%
274,350
-113,250
-29% -$4.24M
CRL icon
19
Charles River Laboratories
CRL
$13.9B
$11M 1.73%
+54,985
New +$9.97M
TFX icon
20
Teleflex
TFX
$5.92B
$10.6M 1.67%
86,876
+46,819
+117% +$5.67M
AVR
21
Anteris Technologies
AVR
$852M
$9.35M 1.47%
1,874,641
+102,040
+6% +$468K
TARA icon
22
Protara Therapeutics
TARA
$226M
$9.14M 1.44%
+1,715,394
New +$9.54M
CCRN
23
DELISTED
Cross Country Healthcare
CCRN
$8.66M 1.36%
+1,068,821
New +$11.7M
HAE icon
24
Haemonetics
HAE
$4.73B
$7.42M 1.17%
92,631
-105,404
-53% -$7.08M
ANIP icon
25
ANI Pharmaceuticals
ANIP
$1.67B
$6.89M 1.08%
87,272
+31,549
+57% +$2.73M
1
2 3 4

Similar funds

EFL
ERn Financial LLC Middleton, Wisconsin $604M AUM 19.83% 1-Year Est. Return
V
VeraBank Henderson, Texas $604M AUM 23.32% 1-Year Est. Return
MAM
Morse Asset Management Darien, Connecticut $604M AUM 72.61% 1-Year Est. Return
RCM
Requisite Capital Management Dallas, Texas $605M AUM 17.2% 1-Year Est. Return
AMG
Advisors Management Group La Crosse, Wisconsin $604M AUM 64.38% 1-Year Est. Return
VV
Verbena Value Westport, Connecticut $605M AUM
VCP
Varenne Capital Partners Paris, France $603M AUM 46.34% 1-Year Est. Return
EHI
Eagle Health Investments Greenwich, Connecticut $603M AUM 111.06% 1-Year Est. Return

Sio Capital Management's Q4 2025 Portfolio in Review

As of Q4 2025, Sio Capital Management held 77 positions worth $636M, up 61% from $395M the previous quarter. Its ten largest holdings account for 54% of the portfolio.

Sio Capital Management deployed $141M of net new capital in Q4 2025, opening 26 new positions and adding to 8 existing holdings. Its largest new stake was Cigna: 172,203 shares worth $47.4M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, up from 84% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Celcuity, an estimated $25.4M trimmed.

  • Sio Capital Management's largest Q4 2025 buy was Cigna: 172,203 shares worth $47.4M.
  • Sio Capital Management added most to Sanofi in Q4 2025, an estimated $20.3M increase.
  • Sio Capital Management's biggest Q4 2025 reduction was Celcuity, cutting an estimated $25.4M.
  • Sio Capital Management fully exited Merck in Q4 2025, selling an estimated $14.9M.
  • Sio Capital Management's ten largest holdings make up 54% of its $636M portfolio in Q4 2025.
  • Sio Capital Management opened 26 new positions and closed 9 in Q4 2025.
  • Sio Capital Management's portfolio value rose 61% quarter-over-quarter to $636M.

Based on Sio Capital Management's 13F filing for Q4 2025, filed 17 Feb 2026.