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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+50.35%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$395M
AUM Growth
+$133M
Cap. Flow
+$73.6M
Cap. Flow %
18.64%
Top 10 Hldgs %
59.5%
Holding
66
New
14
Increased
6
Reduced
13
Closed
15

Top Buys

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$31.5M
2
ALKS icon
Alkermes
ALKS
+$19M
3
SNY icon
Sanofi
SNY
+$18.1M
4
KVUE icon
Kenvue
KVUE
+$17.2M
5
HSIC icon
Henry Schein
HSIC
+$15.2M

Top Sells

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$14.5M
2
NBIX icon
Neurocrine Biosciences
NBIX
+$12.7M
3
DRUG
Bright Minds Biosciences
DRUG
+$12.5M
4
ANNX icon
Annexon
ANNX
+$9.83M
5
SEPN
Septerna Inc
SEPN
+$5.19M

Sector Composition

Rank Sector Weight
1 Healthcare 83.63%
2 Industrials 12.89%
3 Consumer Staples 3.47%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MMS icon
1
Maximus
MMS
$3.2B
$50.9M 12.89%
557,615
+9,529
+2% +$772K
CELC icon
2
Celcuity
CELC
$4.01B
$38.9M 9.83%
+786,526
New +$31.5M
SNY icon
3
Sanofi
SNY
$105B
$26.6M 6.72%
562,703
+375,203
+200% +$18.1M
DNTH icon
4
Dianthus Therapeutics
DNTH
$5.71B
$22.7M 5.75%
577,750
+341,680
+145% +$8.73M
ALKS icon
5
Alkermes
ALKS
$8.79B
$20.2M 5.12%
+674,840
New +$19M
IRON icon
6
Disc Medicine
IRON
$2.85B
$18.8M 4.76%
284,787
– –
MRK icon
7
Merck
MRK
$323B
$14.9M 3.77%
177,300
+3,349
+2% +$276K
HSIC icon
8
Henry Schein
HSIC
$9.64B
$14.5M 3.68%
+219,207
New +$15.2M
CNC icon
9
Centene
CNC
$31.6B
$13.8M 3.5%
387,600
+125,100
+48% +$3.78M
KVUE icon
10
Kenvue
KVUE
$37.4B
$13.7M 3.47%
+844,000
New +$17.2M
BMRN icon
11
BioMarin Pharmaceuticals
BMRN
$11.6B
$12.2M 3.09%
225,114
– –
GSK icon
12
GSK
GSK
$104B
$11.6M 2.94%
+268,873
New +$10.5M
DRUG
13
Bright Minds Biosciences
DRUG
$705M
$11.6M 2.93%
190,764
-321,574
-63% -$12.5M
HAE icon
14
Haemonetics
HAE
$3.63B
$9.65M 2.44%
+198,035
New +$12.3M
AQST icon
15
Aquestive Therapeutics
AQST
$468M
$8.37M 2.12%
1,498,095
+550,606
+58% +$2.38M
KALV
16
DELISTED
KalVista Pharmaceuticals
KALV
$8.33M 2.11%
+683,819
New +$9.45M
AVR
17
Anteris Technologies
AVR
$794M
$7.98M 2.02%
1,772,601
-66,421
-4% -$260K
CRNX icon
18
Crinetics Pharmaceuticals
CRNX
$8.88B
$7.28M 1.84%
+174,841
New +$5.59M
TYRA icon
19
Tyra Biosciences
TYRA
$1.85B
$7.2M 1.82%
514,947
-295,327
-36% -$3.37M
RAPP
20
Rapport Therapeutics
RAPP
$2.02B
$5.5M 1.39%
+185,265
New +$3.3M
NVCR icon
21
NovoCure
NVCR
$1.97B
$5.35M 1.35%
+413,829
New +$5.53M
ANIP icon
22
ANI Pharmaceuticals
ANIP
$1.78B
$5.1M 1.29%
55,723
-57,200
-51% -$4.66M
EWTX icon
23
Edgewise Therapeutics
EWTX
$4.48B
$4.98M 1.26%
307,181
-232,549
-43% -$3.3M
TFX icon
24
Teleflex
TFX
$5.8B
$4.9M 1.24%
+40,057
New +$4.85M
SLP icon
25
Simulations Plus
SLP
$371M
$4.83M 1.22%
+320,307
New +$4.66M
1
2 3

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Sio Capital Management's Q3 2025 Portfolio in Review

As of Q3 2025, Sio Capital Management held 66 positions worth $395M, up 51% from $262M the previous quarter. Its ten largest holdings account for 60% of the portfolio.

Sio Capital Management deployed $73.6M of net new capital in Q3 2025, opening 14 new positions and adding to 6 existing holdings. Its largest new stake was Celcuity: 786,526 shares worth $38.9M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, up from 80% a quarter earlier, followed by Industrials and Consumer Staples.

On the sell side, the largest reduction was Bright Minds Biosciences, an estimated $12.5M trimmed.

  • Sio Capital Management's largest Q3 2025 buy was Celcuity: 786,526 shares worth $38.9M.
  • Sio Capital Management added most to Sanofi in Q3 2025, an estimated $18.1M increase.
  • Sio Capital Management's biggest Q3 2025 reduction was Bright Minds Biosciences, cutting an estimated $12.5M.
  • Sio Capital Management fully exited Globus Medical in Q3 2025, selling an estimated $14.5M.
  • Sio Capital Management's ten largest holdings make up 60% of its $395M portfolio in Q3 2025.
  • Sio Capital Management opened 14 new positions and closed 15 in Q3 2025.
  • Sio Capital Management's portfolio value rose 51% quarter-over-quarter to $395M.

Based on Sio Capital Management's 13F filing for Q3 2025, filed 13 Nov 2025.