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Sio Capital Management Portfolio holdings

AUM $604M
1-Year Est. Return 96.57%
This Fund
S&P 500
This Quarter Est. Return
+0.02%
1 Year Est. Return
+96.57%
3 Year Est. Return
+564.25%
5 Year Est. Return
+486.18%
10 Year Est. Return
+2,856.71%
AUM
$697M
AUM Growth
+$61.6M
Cap. Flow
+$121M
Cap. Flow %
17.37%
Top 10 Hldgs %
45.13%
Holding
90
New
22
Increased
24
Reduced
17
Closed
14

Top Buys

Rank Stock Value
1
COR icon
Cencora
COR
+$29.7M
2
WAY
Waystar Holding Corp
WAY
+$27.3M
3
CORT icon
Corcept Therapeutics
CORT
+$25.2M
4
ICLR icon
Icon
ICLR
+$24.5M
5
MMS icon
Maximus
MMS
+$21.8M

Top Sells

Rank Stock Value
1
CI icon
Cigna
CI
+$47.4M
2
SNY icon
Sanofi
SNY
+$34.1M
3
CELC icon
Celcuity
CELC
+$30.9M
4
ZBH icon
Zimmer Biomet
ZBH
+$29.6M
5
KVUE icon
Kenvue
KVUE
+$25.3M

Sector Composition

Rank Sector Weight
1 Healthcare 92.44%
2 Industrials 7.07%
3 Miscellaneous 0.49%
4 Consumer Staples 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MMS icon
1
Maximus
MMS
$3.13B
$49.3M 7.07%
768,825
+268,521
+54% +$21.8M
WAY
2
Waystar Holding Corp
WAY
$5.03B
$39.6M 5.68%
1,642,236
+1,028,511
+168% +$27.3M
ICLR icon
3
Icon
ICLR
$13.1B
$33.9M 4.86%
306,358
+179,156
+141% +$24.5M
COR icon
4
Cencora
COR
$61.5B
$31.7M 4.55%
100,894
+84,994
+535% +$29.7M
DNTH icon
5
Dianthus Therapeutics
DNTH
$5.92B
$31.1M 4.45%
370,045
-104,458
-22% -$6.05M
AVR
6
Anteris Technologies
AVR
$852M
$29.9M 4.28%
5,382,965
+3,508,324
+187% +$20.2M
CORT icon
7
Corcept Therapeutics
CORT
$12.3B
$27.2M 3.9%
+674,759
New +$25.2M
LIVN icon
8
LivaNova
LIVN
$4.43B
$26.8M 3.84%
421,615
+99,233
+31% +$6.4M
TYRA icon
9
Tyra Biosciences
TYRA
$1.49B
$23.2M 3.33%
605,439
+79,437
+15% +$2.57M
CELC icon
10
Celcuity
CELC
$4.33B
$22.1M 3.17%
193,843
-283,224
-59% -$30.9M
GSK icon
11
GSK
GSK
$102B
$21.3M 3.05%
+385,879
New +$20.9M
ANIP icon
12
ANI Pharmaceuticals
ANIP
$1.67B
$20.4M 2.93%
265,543
+178,271
+204% +$13.9M
ABT icon
13
Abbott
ABT
$195B
$19.2M 2.75%
+186,574
New +$21.1M
EMBC icon
14
Embecta
EMBC
$286M
$16.3M 2.34%
+1,847,850
New +$19.3M
ABVX
15
Abivax
ABVX
$9.89B
$15.1M 2.17%
135,800
+92,676
+215% +$11M
VIR icon
16
Vir Biotechnology
VIR
$1.83B
$13.4M 1.93%
1,498,620
+1,020,277
+213% +$8.13M
HAE icon
17
Haemonetics
HAE
$4.73B
$12.4M 1.78%
220,672
+128,041
+138% +$8.34M
SION
18
Sionna Therapeutics
SION
$265M
$11.8M 1.69%
+294,340
New +$11.2M
SNY icon
19
Sanofi
SNY
$107B
$11.5M 1.66%
239,671
-732,015
-75% -$34.1M
RAPP
20
Rapport Therapeutics
RAPP
$2.34B
$11.5M 1.65%
366,809
+181,544
+98% +$5.11M
TFX icon
21
Teleflex
TFX
$5.92B
$11.3M 1.63%
94,800
+7,924
+9% +$874K
BMRN icon
22
BioMarin Pharmaceuticals
BMRN
$12.5B
$11M 1.57%
194,226
-38,462
-17% -$2.24M
CCRN
23
DELISTED
Cross Country Healthcare
CCRN
$10.3M 1.48%
1,098,393
+29,572
+3% +$265K
TARA icon
24
Protara Therapeutics
TARA
$226M
$10.3M 1.47%
1,969,839
+254,445
+15% +$1.51M
GPCR icon
25
Structure Therapeutics
GPCR
$3.38B
$10.1M 1.45%
209,093
+7,593
+4% +$520K
1
2 3 4

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V
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MAM
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RCM
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AMG
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VV
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VCP
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EHI
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Sio Capital Management's Q1 2026 Portfolio in Review

As of Q1 2026, Sio Capital Management held 90 positions worth $697M, up 9.7% from $636M the previous quarter. Its ten largest holdings account for 45% of the portfolio.

Sio Capital Management deployed $121M of net new capital in Q1 2026, opening 22 new positions and adding to 24 existing holdings. Its largest new stake was Corcept Therapeutics: 674,759 shares worth $27.2M.

By sector, the portfolio is most concentrated in Healthcare at 92% of assets, up from 84% a quarter earlier, followed by Industrials and Miscellaneous.

On the sell side, the largest reduction was Sanofi, an estimated $34.1M trimmed.

  • Sio Capital Management's largest Q1 2026 buy was Corcept Therapeutics: 674,759 shares worth $27.2M.
  • Sio Capital Management added most to Cencora in Q1 2026, an estimated $29.7M increase.
  • Sio Capital Management's biggest Q1 2026 reduction was Sanofi, cutting an estimated $34.1M.
  • Sio Capital Management fully exited Cigna in Q1 2026, selling an estimated $47.4M.
  • Sio Capital Management's ten largest holdings make up 45% of its $697M portfolio in Q1 2026.
  • Sio Capital Management opened 22 new positions and closed 14 in Q1 2026.
  • Sio Capital Management's portfolio value rose 9.7% quarter-over-quarter to $697M.

Based on Sio Capital Management's 13F filing for Q1 2026, filed 14 May 2026.