Simplex Trading’s Septerna Inc SEPN Stock Holding History

Simplex Trading’s Portfolio SEPN Stock Details SEPN Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-53,100	Closed	-$998K	–	10428
2025 Q3	$998K	Sell	53,100 -45,500	-46%	-$597K	﹤0.01%	3046
2025 Q2	$1.04M	Buy	+98,600	New	+$812K	﹤0.01%	2734

Other funds holding SEPN

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

TGV

TRV GP V Boston, Massachusetts $401M AUM 284.76% 1-Year Est. Return

DCM

Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return

TGV

TRV GP VI Boston, Massachusetts $136M AUM 328.39% 1-Year Est. Return

Samsara BioCapital Palo Alto, California $1.03B AUM 214.94% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Siren LLC Greenwich, Connecticut $3.61B AUM 203.3% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return

ACA

Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return

Simplex Trading's SEPN Position: Q3 2025 in Review

Simplex Trading sold out of Septerna Inc (SEPN) in Q3 2025, closing a stake of 23,525 shares — an estimated $309K sold.

Simplex Trading first reported a position in SEPN in Q1 2025 and held it in 2 quarters. The position peaked at $248K in Q2 2025. 82 funds tracked by Wall St. Rank hold SEPN as of Q3 2025.

Simplex Trading reported no remaining Septerna Inc position as of Q3 2025 after selling out during the quarter.
Simplex Trading sold 23,525 Septerna Inc shares in Q3 2025, an estimated $309K.
Simplex Trading first reported a position in Septerna Inc in Q1 2025 and held it in 2 quarters.
Simplex Trading's Septerna Inc position peaked at $248K in Q2 2025.
82 funds tracked by Wall St. Rank held Septerna Inc as of Q3 2025.

Based on Simplex Trading's 13F filing for Q3 2025, filed 12 Nov 2025.