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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 102 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-59
Holders Change %
-8.78%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
102
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
Citigroup
New York
$1.06B
4
Wells Fargo
Wells Fargo
California
$243M
5
JFG
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
Demars Financial Group
Washington
$247K
2
UBS Group
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$631M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
Squarepoint
New York
$39.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
MC
451
Moors & Cabot
Massachusetts
$217K -$113K -1,365 -34%
RWP
452
RWA Wealth Partners
Massachusetts
$216K -$77K -929 -26%
Lido Advisors
453
Lido Advisors
California
$215K -$746 -9 -0.3%
Blackstone Inc
454
Blackstone Inc
New York
$211K -$19.4M -234,212 -99%
RA
455
RFG Advisory
Alabama
$208K +$208K +2,507 New
GVAG
456
Great Valley Advisor Group
Delaware
$206K -$21.3K -258 -9%
MIM
457
Macroview Investment Management
Maryland
$205K -$32K -386 -13%
MFG
458
Merit Financial Group
Georgia
$203K +$203K +2,449 New
CIAS
459
Capital Investment Advisory Services
North Carolina
$203K +$95K +1,145 +88%
GFG
460
Grantvest Financial Group
New Jersey
$201K +$201K +2,426 New
SI
461
Stephens Inc
Arkansas
$201K -$48.5K -585 -19%
GWM
462
Geneos Wealth Management
Colorado
$197K -$106K -1,282 -35%
MIM
463
MetLife Investment Management
New Jersey
$180K +$20.4K +246 +13%
DWS
464
Dynamic Wealth Strategies
California
$176K +$18.2K +219 +12%
ACA
465
Aptus Capital Advisors
Alabama
$169K – – –
WSFS
466
Wilmington Savings Fund Society
Delaware
$167K -$267K -3,216 -61%
TH
467
TCTC Holdings
Texas
$166K – – –
Parallax Volatility Advisers
468
Parallax Volatility Advisers
California
$154K -$1.12M -13,478 -88%
AF
469
Allworth Financial
California
$147K +$116K +1,400 +379%
ST
470
Skorpios Trust
Cyprus
$140K – – –
S
471
SignatureFD
Georgia
$140K -$8.29K -100 -6%
GFL
472
Granite FO LLC
New Hampshire
$129K – – –
JEST
473
JTC Employer Solutions Trustee
Jersey
$128K – – –
CT
474
Colonial Trust
South Carolina
$124K – – –
OC
475
Oakworth Capital
Alabama
$118K -$232K -2,803 -66%
17 18
19
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