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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 102 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-59
Holders Change %
-8.78%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
102
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
Citigroup
New York
$1.06B
4
Wells Fargo
Wells Fargo
California
$243M
5
JFG
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
Demars Financial Group
Washington
$247K
2
UBS Group
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$631M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
Squarepoint
New York
$39.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
PCTC
376
Perkins Coie Trust Company
Washington
$363K -$37.3K -450 -9%
FA
377
Fiduciary Alliance
South Carolina
$362K +$26.8K +323 +8%
PCFFS
378
Pacific Center for Financial Services
California
$362K – – –
CMMS
379
Comprehensive Money Management Services
Florida
$361K -$24K -289 -6%
PIA
380
Powell Investment Advisors
Florida
$352K +$74.6K +900 +27%
ATC
381
Advantage Trust Company
Kansas
$352K +$41.5K +500 +13%
SWP
382
Stratos Wealth Partners
Ohio
$349K +$3.24K +39 +0.9%
SIG
383
Sargent Investment Group
Maryland
$349K -$6.89K -80 -2%
BFF
384
Byrne Financial Freedom
Massachusetts
$348K -$31.1K -375 -8%
SIC
385
Salem Investment Counselors
North Carolina
$346K -$35.2K -425 -9%
LSA
386
Lion Street Advisors
Texas
$344K -$18.2K -220 -5%
EFS
387
Essex Financial Services
Connecticut
$342K +$130K +1,563 +61%
NEPWA
388
New England Private Wealth Advisors
Massachusetts
$340K -$18K -209 -5%
VPA
389
Vernal Point Advisors
California
$339K – – –
JJBC
390
James J. Burns & Company
New York
$339K +$85.2K +1,027 +34%
ISL
391
Ingalls & Snyder LLC
New York
$336K -$8.28K -100 -2%
Marshall Wace
392
Marshall Wace
United Kingdom
$334K -$1.74M -20,971 -84%
AIM
393
Anchor Investment Management
South Carolina
$331K -$58K -699 -15%
BO
394
Bank OZK
Arkansas
$329K – – –
AWM
395
Accredited Wealth Management
Kentucky
$326K +$323K +3,900 +15,600%
IA
396
IFP Advisors
Florida
$324K +$60.3K +727 +23%
WSC
397
Wellington Shields & Co
New York
$323K – – –
BAAM
398
Baker Avenue Asset Management
California
$322K +$322K +3,882 New
KPWS
399
Kestra Private Wealth Services
Texas
$318K -$1.13M -13,637 -78%
First Manhattan
400
First Manhattan
New York
$315K -$829 -10 -0.3%
14 15
16
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