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SPDR S&P Biotech ETF
XBI

Overview Fund Activity

613 hedge funds and large institutions have $9.73B invested in SPDR S&P Biotech ETF in 2025 Q2 according to their latest regulatory filings, with 54 funds opening new positions, 159 increasing their positions, 270 reducing their positions, and 102 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
613
Holders Change
-59
Holders Change %
-8.78%
% of All Funds
8.22%
Holding in Top 10
15
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.2%
New
54
Increased
159
Reduced
270
Closed
102
Calls
$1.47B
Puts
$2.24B
Net Calls
-$777M
Net Calls Change
+$309M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
$1.5B
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$1.01B
3
Citigroup
Citigroup
New York
$1.06B
4
Wells Fargo
Wells Fargo
California
$243M
5
JFG
Jefferies Financial Group
New York
$119M

Top Sellers

1
DFG
Demars Financial Group
Washington
$247K
2
UBS Group
UBS Group
Switzerland
$341M
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$631M
4
HIIFS
Harel Insurance Investments & Financial Services
Israel
$0
5
Squarepoint
Squarepoint
New York
$39.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
BBHC
351
Brown Brothers Harriman & Co
New York
$418K +$11.1K +134 +3%
MMH
352
Menora Mivtachim Holdings
Israel
$415K – – –
NS
353
NBC Securities
Alabama
$412K +$20K +241 +5%
US Bancorp
354
US Bancorp
Minnesota
$410K -$47.8K -577 -10%
ACM
355
Ascent Capital Management
Oregon
$409K +$83 +1 +0%
Toronto Dominion Bank
356
Toronto Dominion Bank
Ontario, Canada
$406K -$41.1K -496 -9%
HL
357
HeadInvest LLC
Maine
$402K -$2.99K -36 -0.7%
Pathstone Holdings
358
Pathstone Holdings
New Jersey
$401K -$43.6K -526 -10%
KA
359
Kovack Advisors
Florida
$400K -$44.9K -541 -10%
MC
360
Mathes Company
New York
$396K -$147K -1,775 -27%
FNBT
361
FineMark National Bank & Trust
Florida
$392K -$6.3K -76 -2%
HG
362
Herbst Group
Connecticut
$392K -$415 -5 -0.1%
AAS
363
Avantax Advisory Services
Texas
$392K -$199K -2,401 -34%
RSWM
364
Robertson Stephens Wealth Management
California
$392K +$105K +1,261 +36%
JCM
365
Jacobi Capital Management
Pennsylvania
$391K -$12.2K -147 -3%
LI
366
LMCG Investments
Massachusetts
$391K -$1.83M -22,100 -82%
Bank of New York Mellon
367
Bank of New York Mellon
New York
$388K +$49.7K +599 +15%
MFIM
368
Mesirow Financial Investment Management
Illinois
$377K -$338K -4,071 -47%
IC
369
IEQ Capital
California
$376K +$14.1K +170 +4%
MOS
370
MGO One Seven
Ohio
$373K -$14.9K -180 -4%
GIM
371
Glenmede Investment Management
Pennsylvania
$373K +$373K +4,500 New
FLC
372
Fifth Lane Capital
Texas
$373K +$373K +4,500 New
Zurich Cantonal Bank
373
Zurich Cantonal Bank
Switzerland
$372K -$7.47K -90 -2%
CCG
374
Chatham Capital Group
Georgia
$366K -$46.4K -560 -11%
BA
375
Bridgewater Advisors
New York
$364K -$59.8K -697 -14%
13 14
15
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