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UPB

Upstream Bio Inc
UPB

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$118M +$160M +7,176,187 New
O
2
OrbiMed
New York
$93.6M +$127M +5,693,589 New
DC
3
Decheng Capital
California
$54M +$73.4M +3,285,293 New
TCM
4
TCG Crossover Management
California
$44.9M +$62.6M +2,801,763 New
ES
5
Enavate Sciences
California
$40.4M +$54.9M +2,459,703 New
BCLSI
6
Bain Capital Life Sciences Investors
Massachusetts
$37.7M +$51.3M +2,295,322 New
VA
7
VR Adviser
New York
$37.7M +$51.3M +2,295,319 New
SB
8
Samsara BioCapital
California
$36.4M +$49.5M +2,217,146 New
OFM
9
Omega Fund Management
Massachusetts
$33.5M +$45.5M +2,036,293 New
Wellington Management Group
10
Wellington Management Group
Massachusetts
$25.6M +$35.3M +1,583,154 New
BlackRock
11
BlackRock
New York
$18.4M +$25M +1,117,800 New
AllianceBernstein
12
AllianceBernstein
Tennessee
$18.3M +$24.8M +1,111,337 New
DTC
13
Deep Track Capital
Connecticut
$16.4M +$22.3M +1,000,000 New
Norges Bank
14
Norges Bank
Norway
$16.4M +$22.3M +1,000,000 New
Vanguard Group
15
Vanguard Group
Pennsylvania
$15M +$20.4M +915,021 New
SL
16
Siren LLC
Connecticut
$13.2M +$17.9M +800,000 New
NCM
17
Nantahala Capital Management
Connecticut
$9.86M +$13.4M +600,000 New
WP
18
Woodline Partners
California
$8.66M +$11.8M +526,511 New
Geode Capital Management
19
Geode Capital Management
Massachusetts
$5.97M +$8.11M +363,269 New
Balyasny Asset Management
20
Balyasny Asset Management
Illinois
$4.95M +$6.72M +301,152 New
GPP
21
Great Point Partners
Connecticut
$4.93M +$6.7M +300,000 New
Marshall Wace
22
Marshall Wace
United Kingdom
$4.78M +$6.49M +290,734 New
State Street
23
State Street
Massachusetts
$4.06M +$5.52M +247,187 New
LCM
24
Lynx1 Capital Management
Puerto Rico
$3.95M +$5.36M +240,042 New
Citadel Advisors
25
Citadel Advisors
Florida
$2.96M +$4.02M +180,000 New
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