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Tyra Biosciences
TYRA

121 hedge funds and large institutions have $542M invested in Tyra Biosciences in 2025 Q2 according to their latest regulatory filings, with 18 funds opening new positions, 62 increasing their positions, 20 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

210% more repeat investments, than reductions

Existing positions increased: 62 | Existing positions reduced: 20

29% more first-time investments, than exits

New positions opened: 18 | Existing positions closed: 14

8% more capital invested

Capital invested by funds: $500M → $542M (+$42M)

5.68% more ownership

Funds ownership: 100.91% → 106.59% (+5.7%)

3% more funds holding

Funds holding: 117 → 121 (+4)

25% less funds holding in top 10

Funds holding in top 10: 4 → 3 (-1)

Holders
121
Holders Change
+4
Holders Change %
+3.42%
% of All Funds
1.59%
Holding in Top 10
3
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-25%
% of All Funds
0.04%
New
18
Increased
62
Reduced
20
Closed
14
Calls
$1K
Puts
–
Net Calls
+$1K
Net Calls Change
-$182K

Top Buyers

Rank Fund Capital Flow
1
CC
Commodore Capital
New York
+$20.4M
2
RCM
RA Capital Management
Massachusetts
+$14.8M
3
SCM
Sio Capital Management
New York
+$3.74M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$3.23M
5
Bank of America
Bank of America
North Carolina
+$2.75M

Top Sellers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
-$16.1M
2
O
OrbiMed
New York
-$9.01M
3
CPX
Canaan Partners XI
California
-$5.1M
4
Pictet Asset Management
Pictet Asset Management
Switzerland
-$4.27M
5
VPC
Vestal Point Capital
New York
-$2.14M
Name Holding Trade Value Shares
Change 		Change in
Stake
Point72 Asset Management
26
Point72 Asset Management
Connecticut
$2.15M +$1.66M +175,100 +353%
Citadel Advisors
27
Citadel Advisors
Florida
$2.07M +$1.14M +119,854 +124%
Northern Trust
28
Northern Trust
Illinois
$1.96M -$106K -11,139 -5%
CP
29
Caligan Partners
New York
$1.82M +$1.57M +164,950 +660%
Charles Schwab
30
Charles Schwab
California
$1.7M +$133K +13,996 +9%
Renaissance Technologies
31
Renaissance Technologies
New York
$1.29M +$795K +83,700 +163%
Axa
32
Axa
France
$1.23M +$2K +211 +0.2%
CSS
33
Cubist Systematic Strategies
Connecticut
$1.17M +$287K +30,192 +33%
Two Sigma Investments
34
Two Sigma Investments
New York
$1.01M +$390K +41,007 +63%
Goldman Sachs
35
Goldman Sachs
New York
$1.01M +$262K +27,589 +35%
Wellington Management Group
36
Wellington Management Group
Massachusetts
$986K -$9.59K -1,009 -1%
JP Morgan Chase
37
JP Morgan Chase
New York
$985K +$166K +17,427 +20%
WP
38
Woodline Partners
California
$958K – – –
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
$935K +$274K +28,786 +42%
Two Sigma Advisers
40
Two Sigma Advisers
New York
$833K +$351K +36,900 +74%
ICCON
41
Investment Counsel Company of Nevada
Nevada
$814K – – –
Ameriprise
42
Ameriprise
Minnesota
$771K +$766K +80,602 New
N
43
Nuveen
North Carolina
$770K +$289K +30,443 +61%
State of Wisconsin Investment Board
44
State of Wisconsin Investment Board
Wisconsin
$732K +$169K +17,737 +30%
OC
45
Oppenheimer & Co
New York
$708K -$7.33K -772 -1%
A
46
AlphaQuest
New York
$699K +$413K +43,451 +147%
JF
47
Jump Financial
Illinois
$681K +$410K +43,170 +154%
ECM
48
ExodusPoint Capital Management
New York
$645K +$354K +37,207 +123%
Raymond James Financial
49
Raymond James Financial
Florida
$605K +$84K +8,843 +16%
Barclays
50
Barclays
United Kingdom
$589K +$181K +19,044 +45%
1
2
3 4 5

TYRA Hedge Fund Activity: Q2 2025 in Review

121 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Tyra Biosciences (TYRA) for Q2 2025, worth a combined $542M — up 8.4% from $500M a quarter earlier.

Buyers outnumbered sellers: 18 funds opened new TYRA positions and 14 closed out — a net gain of 4 holders — while 62 added to existing stakes and 20 trimmed.

The largest buyer was Commodore Capital, adding an estimated $20.4M. The largest seller was Fidelity Investments, cutting an estimated $16.1M.

  • 121 institutional investors held Tyra Biosciences (TYRA) as of Q2 2025, up from 117 in Q1 2025.
  • Funds reported $542M of Tyra Biosciences stock for Q2 2025, up 8.4% quarter-over-quarter.
  • 18 funds opened new Tyra Biosciences positions in Q2 2025 and 14 closed out, a net change of +4 holders.
  • The largest Tyra Biosciences buyer in Q2 2025 was Commodore Capital, an estimated $20.4M added.
  • The largest Tyra Biosciences seller in Q2 2025 was Fidelity Investments, an estimated $16.1M sold.

Based on aggregated 13F filings for Q2 2025.