Two Sigma Advisers
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Two Sigma Advisers’s Tyra Biosciences TYRA Stock Holding History

Two Sigma Advisers’s Portfolio TYRA Stock Details TYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-58,900
Closed -$1.55M – 2021
2025
Q4 		$1.55M Sell
58,900
-54,300
-48% -$997K ﹤0.01% 1287
2025
Q3 		$1.58M Buy
113,200
+26,200
+30% +$299K ﹤0.01% 1241
2025
Q2 		$833K Buy
87,000
+36,900
+74% +$351K ﹤0.01% 1527
2025
Q1 		$466K Buy
50,100
+37,800
+307% +$489K ﹤0.01% 1810
2024
Q4 		$171K Buy
+12,300
New +$223K ﹤0.01% 2150

Other funds holding TYRA

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
APMC
Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return
FCM
Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Two Sigma Advisers's TYRA Position: Q1 2026 in Review

Two Sigma Advisers sold out of Tyra Biosciences (TYRA) in Q1 2026, closing a stake of 58,900 shares — an estimated $1.55M sold.

Two Sigma Advisers first reported a position in TYRA in Q4 2024 and held it in 5 quarters. The position peaked at $1.58M in Q3 2025. 164 funds tracked by Wall St. Rank hold TYRA as of Q1 2026.

  • Two Sigma Advisers reported no remaining Tyra Biosciences position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Advisers sold 58,900 Tyra Biosciences shares in Q1 2026, an estimated $1.55M.
  • Two Sigma Advisers first reported a position in Tyra Biosciences in Q4 2024 and held it in 5 quarters.
  • Two Sigma Advisers's Tyra Biosciences position peaked at $1.58M in Q3 2025.
  • 164 funds tracked by Wall St. Rank held Tyra Biosciences as of Q1 2026.

Based on Two Sigma Advisers's 13F filing for Q1 2026.