Renaissance Technologies
TYRA icon

Renaissance Technologies’s Tyra Biosciences TYRA Stock Holding History

Renaissance Technologies’s Portfolio TYRA Stock Details TYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-170,100
Closed -$2.38M – 3774
2025
Q3 		$2.38M Buy
170,100
+35,000
+26% +$399K ﹤0.01% 1955
2025
Q2 		$1.29M Buy
135,100
+83,700
+163% +$795K ﹤0.01% 2370
2025
Q1 		$478K Buy
51,400
+22,300
+77% +$289K ﹤0.01% 2764
2024
Q4 		$404K Buy
+29,100
New +$528K ﹤0.01% 2946
2024
Q2 		– Sell
-54,400
Closed -$892K – 3973
2024
Q1 		$892K Buy
+54,400
New +$892K ﹤0.01% 2556
2022
Q2 		– Sell
-29,300
Closed -$314K – 4585
2022
Q1 		$314K Sell
29,300
-61,700
-68% -$732K ﹤0.01% 3455
2021
Q4 		$1.28M Buy
+91,000
New +$1.81M ﹤0.01% 2466

Other funds holding TYRA

RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return
APMC
Alta Partners Management Company Jackson, Wyoming $151M AUM 296.21% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
CPX
Canaan Partners XI Menlo Park, California $76.1M AUM 638.59% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

Renaissance Technologies's TYRA Position: Q4 2025 in Review

Renaissance Technologies sold out of Tyra Biosciences (TYRA) in Q4 2025, closing a stake of 170,100 shares — an estimated $2.38M sold.

Renaissance Technologies first reported a position in TYRA in Q4 2021 and held it in 7 quarters. The position peaked at $2.38M in Q3 2025. 133 funds tracked by Wall St. Rank hold TYRA as of Q4 2025.

  • Renaissance Technologies reported no remaining Tyra Biosciences position as of Q4 2025 after selling out during the quarter.
  • Renaissance Technologies sold 170,100 Tyra Biosciences shares in Q4 2025, an estimated $2.38M.
  • Renaissance Technologies first reported a position in Tyra Biosciences in Q4 2021 and held it in 7 quarters.
  • Renaissance Technologies's Tyra Biosciences position peaked at $2.38M in Q3 2025.
  • 133 funds tracked by Wall St. Rank held Tyra Biosciences as of Q4 2025.

Based on Renaissance Technologies's 13F filing for Q4 2025, filed 12 Feb 2026.