Two Sigma Investments’s Tyra Biosciences TYRA Stock Holding History

Two Sigma Investments’s Portfolio TYRA Stock Details TYRA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q1	$3.89M	Sell	101,618 -5,405	-5%	-$175K	﹤0.01%	2200
2025 Q4	$2.81M	Sell	107,023 -92,415	-46%	-$1.7M	﹤0.01%	2180
2025 Q3	$2.79M	Buy	199,438 +93,613	+88%	+$1.07M	﹤0.01%	1900
2025 Q2	$1.01M	Buy	105,825 +41,007	+63%	+$390K	﹤0.01%	2242
2025 Q1	$603K	Buy	64,818 +18,549	+40%	+$240K	﹤0.01%	2440
2024 Q4	$643K	Buy	46,269 +7,093	+18%	+$129K	﹤0.01%	2416
2024 Q3	$921K	Buy	39,176 +3,904	+11%	+$82K	﹤0.01%	2171
2024 Q2	$564K	Sell	35,272 -6,470	-15%	-$111K	﹤0.01%	2310
2024 Q1	$685K	Buy	+41,742	New	+$685K	﹤0.01%	2180

Other funds holding TYRA

RCM

RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

Nextech Invest Zurich, Switzerland $1.42B AUM 304.47% 1-Year Est. Return

Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return

APMC

Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return

FCM

Farallon Capital Management San Francisco, California $17.5B AUM 50.95% 1-Year Est. Return

TCM

TCG Crossover Management Palo Alto, California $3.5B AUM 1,165.83% 1-Year Est. Return

Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return

BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return

PBA

Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return

Two Sigma Investments's TYRA Position: Q1 2026 in Review

Two Sigma Investments reduced its Tyra Biosciences (TYRA) stake by 5.1% in Q1 2026, selling an estimated $175K and leaving 101,618 shares worth $3.89M. The position accounts for ﹤0.01% of the portfolio, ranked #2200.

Two Sigma Investments first reported a position in TYRA in Q1 2024 and has held it in 9 quarters since. 164 funds tracked by Wall St. Rank hold TYRA as of Q1 2026.

Two Sigma Investments held 101,618 shares of Tyra Biosciences worth $3.89M as of Q1 2026.
Two Sigma Investments sold 5,405 Tyra Biosciences shares in Q1 2026, an estimated $175K.
Tyra Biosciences made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2200 holding.
Two Sigma Investments first reported a position in Tyra Biosciences in Q1 2024 and has held it in 9 quarters since.
164 funds tracked by Wall St. Rank held Tyra Biosciences as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.