Two Sigma Investments
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Two Sigma Investments’s Tyra Biosciences TYRA Stock Holding History

Two Sigma Investments’s Portfolio TYRA Stock Details TYRA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$14.4M Buy
449,808
+348,190
+343% +$11.5M 0.01% 1255
2026
Q1 		$3.89M Sell
101,618
-5,405
-5% -$175K ﹤0.01% 2200
2025
Q4 		$2.81M Sell
107,023
-92,415
-46% -$1.7M ﹤0.01% 2180
2025
Q3 		$2.79M Buy
199,438
+93,613
+88% +$1.07M ﹤0.01% 1900
2025
Q2 		$1.01M Buy
105,825
+41,007
+63% +$390K ﹤0.01% 2242
2025
Q1 		$603K Buy
64,818
+18,549
+40% +$240K ﹤0.01% 2440
2024
Q4 		$643K Buy
46,269
+7,093
+18% +$129K ﹤0.01% 2416
2024
Q3 		$921K Buy
39,176
+3,904
+11% +$82K ﹤0.01% 2171
2024
Q2 		$564K Sell
35,272
-6,470
-15% -$111K ﹤0.01% 2310
2024
Q1 		$685K Buy
+41,742
New +$685K ﹤0.01% 2180

Other funds holding TYRA

RCM
RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return
Fidelity Investments
Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return
JT
Jupiter Topco New York $245B AUM
APMC
Alta Partners Management Company Jackson, Wyoming $127M AUM 230.85% 1-Year Est. Return
NI
Nextech Invest Zurich, Switzerland $2.11B AUM 413.84% 1-Year Est. Return
TCM
TCG Crossover Management Palo Alto, California $4.16B AUM 983.43% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return
CC
Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return

Two Sigma Investments's TYRA Position: Q2 2026 in Review

Two Sigma Investments increased its Tyra Biosciences (TYRA) stake by 343% in Q2 2026, buying an estimated $11.5M and bringing the position to 449,808 shares worth $14.4M. The position accounts for 0.01% of the portfolio, ranked #1255.

Two Sigma Investments first reported a position in TYRA in Q1 2024 and has held it in 10 quarters since. 168 funds tracked by Wall St. Rank hold TYRA as of Q2 2026.

  • Two Sigma Investments held 449,808 shares of Tyra Biosciences worth $14.4M as of Q2 2026.
  • Two Sigma Investments bought 348,190 Tyra Biosciences shares in Q2 2026, an estimated $11.5M.
  • Tyra Biosciences made up 0.01% of Two Sigma Investments's portfolio in Q2 2026, its #1255 holding.
  • Two Sigma Investments first reported a position in Tyra Biosciences in Q1 2024 and has held it in 10 quarters since.
  • 168 funds tracked by Wall St. Rank held Tyra Biosciences as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.