Septerna Inc
SEPN
122 hedge funds and large institutions have $1.27B invested in Septerna Inc in 2025 Q4 according to their latest regulatory filings, with 45 funds opening new positions, 31 increasing their positions, 27 reducing their positions, and 5 closing their positions.
800% more first-time investments, than exits
New positions opened: 45 | Existing positions closed: 5
52% more capital invested
Capital invested by funds: $838M → $1.27B (+$433M)
49% more funds holding
Funds holding: 82 → 122 (+40)
25% more funds holding in top 10
Funds holding in top 10: 4 → 5 (+1)
15% more repeat investments, than reductions
Existing positions increased: 31 | Existing positions reduced: 27
1.9% more ownership
Funds ownership: 99.92% → 101.82% (+1.9%)
54% less call options, than puts
Call options by funds: $2.3M | Put options by funds: $5.01M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Goldman Sachs
New York
|
+$30.1M |
| 2 |
FLAM
First Light Asset Management
Edina,
Minnesota
|
+$14.8M |
| 3 |
Primecap Management
Pasadena,
California
|
+$13M |
| 4 |
SCM
Soleus Capital Management
Greenwich,
Connecticut
|
+$8.72M |
| 5 |
BlackRock
New York
|
+$8.16M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BI
BVF Inc
San Francisco,
California
|
-$54.8M |
| 2 |
Millennium Management
New York
|
-$6.61M |
| 3 |
CC
Checkpoint Capital
San Francisco,
California
|
-$5.33M |
| 4 |
SL
Siren LLC
Greenwich,
Connecticut
|
-$4.84M |
| 5 |
SCM
Sio Capital Management
New York
|
-$3.56M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
126
Verition Fund Management
Greenwich,
Connecticut
| – | -$379K | -20,131 | Closed |
|
127
National Bank of Canada
Montreal,
Quebec, Canada
| – | -$150 | -8 | Closed |
|
SEPN Hedge Fund Activity: Q4 2025 in Review
122 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Septerna Inc (SEPN) for Q4 2025, worth a combined $1.27B — up 52% from $838M a quarter earlier.
Buyers outnumbered sellers: 45 funds opened new SEPN positions and 5 closed out — a net gain of 40 holders — while 31 added to existing stakes and 27 trimmed.
The largest buyer was Goldman Sachs, adding an estimated $30.1M. The largest seller was BVF Inc, cutting an estimated $54.8M.
- 122 institutional investors held Septerna Inc (SEPN) as of Q4 2025, up from 82 in Q3 2025.
- Funds reported $1.27B of Septerna Inc stock for Q4 2025, up 52% quarter-over-quarter.
- 45 funds opened new Septerna Inc positions in Q4 2025 and 5 closed out, a net change of +40 holders.
- The largest Septerna Inc buyer in Q4 2025 was Goldman Sachs, an estimated $30.1M added.
- The largest Septerna Inc seller in Q4 2025 was BVF Inc, an estimated $54.8M sold.
Based on aggregated 13F filings for Q4 2025.