LYRA THERAPEUTICS INC
LYRA
LYRA was delisted on the 16th of March, 2026.
23 hedge funds and large institutions have $747K invested in LYRA THERAPEUTICS INC in 2025 Q4 according to their latest regulatory filings, with 3 funds opening new positions, 6 increasing their positions, 6 reducing their positions, and 6 closing their positions.
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
0% more repeat investments, than reductions
Existing positions increased: 6 | Existing positions reduced: 6
12% less funds holding
Funds holding: 26 → 23 (-3)
13.61% less ownership
Funds ownership: 27.28% → 13.67% (-14%)
50% less first-time investments, than exits
New positions opened: 3 | Existing positions closed: 6
75% less capital invested
Capital invested by funds: $2.93M → $747K (-$2.19M)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
SM
Sabby Management
Miami Beach,
Florida
|
+$237K |
| 2 |
DS
DRW Securities
Chicago,
Illinois
|
+$83.6K |
| 3 |
AGP
Artia Global Partners
Miami,
Florida
|
+$43.6K |
| 4 |
TRCT
Tower Research Capital (TRC)
New York
|
+$8.24K |
| 5 |
Geode Capital Management
Boston,
Massachusetts
|
+$6.28K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
PA
Perceptive Advisors
New York
|
-$1.5M |
| 2 |
Vanguard Group
Malvern,
Pennsylvania
|
-$189K |
| 3 |
Citadel Advisors
Miami,
Florida
|
-$128K |
| 4 |
UBS Group
Zurich,
Switzerland
|
-$16.5K |
| 5 |
Morgan Stanley
New York
|
-$4.69K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
26
Fidelity Investments
Boston,
Massachusetts
| – | -$2.68K | -406 | Closed |
|
|
SRCM
27
Signature Resources Capital Management
Newport Beach,
California
| – | -$2.61K | -400 | Closed |
|
|
FFO
28
Fortitude Family Office
Scottsdale,
Arizona
| – | -$627 | -96 | Closed |
|
29
Carson Wealth (CWM LLC)
Omaha,
Nebraska
| – | -$114 | -23 | -96% |
|
LYRA Hedge Fund Activity: Q4 2025 in Review
23 of the 8,238 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q4 2025, worth a combined $747K — down 75% from $2.93M a quarter earlier.
Sellers outnumbered buyers: 6 funds closed out of LYRA and 3 opened new positions — a net loss of 3 holders — while 6 trimmed existing stakes and 6 added.
The largest buyer was Sabby Management, adding an estimated $237K. The largest seller was Perceptive Advisors, exiting entirely with an estimated $1.5M sold.
- 23 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q4 2025, down from 26 in Q3 2025.
- Funds reported $747K of LYRA THERAPEUTICS INC stock for Q4 2025, down 75% quarter-over-quarter.
- 3 funds opened new LYRA THERAPEUTICS INC positions in Q4 2025 and 6 closed out, a net change of -3 holders.
- The largest LYRA THERAPEUTICS INC buyer in Q4 2025 was Sabby Management, an estimated $237K added.
- The largest LYRA THERAPEUTICS INC seller in Q4 2025 was Perceptive Advisors, an estimated $1.5M sold.
Based on aggregated 13F filings for Q4 2025.