LYRA THERAPEUTICS INC
LYRA
LYRA was delisted on the 16th of March, 2026.
26 hedge funds and large institutions have $2.93M invested in LYRA THERAPEUTICS INC in 2025 Q3 according to their latest regulatory filings, with 4 funds opening new positions, 4 increasing their positions, 13 reducing their positions, and 8 closing their positions.
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
10% less ownership
Funds ownership: 37.28% → 27.28% (-10%)
13% less funds holding
Funds holding: 30 → 26 (-4)
34% less capital invested
Capital invested by funds: $4.42M → $2.93M (-$1.49M)
50% less first-time investments, than exits
New positions opened: 4 | Existing positions closed: 8
69% less repeat investments, than reductions
Existing positions increased: 4 | Existing positions reduced: 13
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Citadel Advisors
Miami,
Florida
|
+$143K |
| 2 |
UBS Group
Zurich,
Switzerland
|
+$29.3K |
| 3 |
SM
Sabby Management
Miami Beach,
Florida
|
+$13.9K |
| 4 |
Royal Bank of Canada
Toronto,
Ontario, Canada
|
+$1.64K |
| 5 |
Jones Financial Companies
Des Peres,
Missouri
|
+$1.47K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Bank of America
Charlotte,
North Carolina
|
-$209K |
| 2 |
PA
Perceptive Advisors
New York
|
-$189K |
| 3 |
State of Wisconsin Investment Board
Madison,
Wisconsin
|
-$94.1K |
| 4 |
Russell Investments Group
London,
United Kingdom
|
-$14.3K |
| 5 |
Fidelity Investments
Boston,
Massachusetts
|
-$9.84K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
26
State of Wisconsin Investment Board
Madison,
Wisconsin
| – | -$94.1K | -10,500 | Closed |
|
|
27
Russell Investments Group
London,
United Kingdom
| – | -$14.3K | -1,594 | Closed |
|
|
VNA
28
Valley National Advisers
Bethlehem,
Pennsylvania
| – | -$4K | -500 | Closed |
|
29
Carson Wealth (CWM LLC)
Omaha,
Nebraska
| – | -$1.3K | -178 | -88% |
|
30
Barclays
London,
United Kingdom
| – | -$430 | -48 | Closed |
|
31
Wells Fargo
San Francisco,
California
| – | -$349 | -39 | Closed |
|
|
PS
32
Principal Securities
Des Moines,
Iowa
| – | -$170 | -19 | Closed |
|
33
Nisa Investment Advisors
St. Louis,
Missouri
| – | -$90 | -10 | Closed |
|
34
Raymond James Financial
St Petersburg,
Florida
| – | -$72 | -8 | Closed |
|
LYRA Hedge Fund Activity: Q3 2025 in Review
26 of the 7,624 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q3 2025, worth a combined $2.93M — down 34% from $4.42M a quarter earlier.
Sellers outnumbered buyers: 8 funds closed out of LYRA and 4 opened new positions — a net loss of 4 holders — while 13 trimmed existing stakes and 4 added.
The largest buyer was Citadel Advisors, opening a new position worth an estimated $143K. The largest seller was Bank of America, cutting an estimated $209K.
- 26 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q3 2025, down from 30 in Q2 2025.
- Funds reported $2.93M of LYRA THERAPEUTICS INC stock for Q3 2025, down 34% quarter-over-quarter.
- 4 funds opened new LYRA THERAPEUTICS INC positions in Q3 2025 and 8 closed out, a net change of -4 holders.
- The largest LYRA THERAPEUTICS INC buyer in Q3 2025 was Citadel Advisors, an estimated $143K added.
- The largest LYRA THERAPEUTICS INC seller in Q3 2025 was Bank of America, an estimated $209K sold.
Based on aggregated 13F filings for Q3 2025.