LYRA THERAPEUTICS INC
LYRA
LYRA was delisted on the 16th of March, 2026.
36 hedge funds and large institutions have $109M invested in LYRA THERAPEUTICS INC in 2022 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 9 increasing their positions, 8 reducing their positions, and 4 closing their positions.
439% more capital invested
Capital invested by funds: $20.2M → $109M (+$88.7M)
250% more first-time investments, than exits
New positions opened: 14 | Existing positions closed: 4
38% more funds holding
Funds holding: 26 → 36 (+10)
13% more repeat investments, than reductions
Existing positions increased: 9 | Existing positions reduced: 8
0.44% more ownership
Funds ownership: 0.77% → 1.21% (+0.44%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
PA
Perceptive Advisors
New York
|
+$32.3M |
| 2 |
NCM
Nantahala Capital Management
New Canaan,
Connecticut
|
+$12.9M |
| 3 |
PVI
Pura Vida Investments
New York
|
+$11.2M |
| 4 |
SB
Samsara BioCapital
Palo Alto,
California
|
+$9.68M |
| 5 |
VA
VR Adviser
New York
|
+$5.03M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
IC
Ikarian Capital
Dallas,
Texas
|
-$408K |
| 2 |
PCM
Pentwater Capital Management
Naples,
Florida
|
-$241K |
| 3 |
Millennium Management
New York
|
-$131K |
| 4 |
BCM
Bridgeway Capital Management
Houston,
Texas
|
-$54.4K |
| 5 |
JP Morgan Chase
New York
|
-$41.9K |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
TRCT
26
Tower Research Capital (TRC)
New York
| $5K | +$4.9K | +18 | New |
|
|
WAM
27
Worth Asset Management
Dallas,
Texas
| $4K | – | – | – |
|
|
LWANC
28
Laurel Wealth Advisors (North Carolina)
Charlotte,
North Carolina
| $3K | – | – | – |
|
29
Osaic Holdings
Scottsdale,
Arizona
| $3K | – | – | – |
|
30
US Bancorp
Minneapolis,
Minnesota
| $3K | – | – | – |
|
|
TWC
31
TD Waterhouse Canada
Toronto,
Ontario, Canada
| $1.07K | – | – | – |
|
32
Wells Fargo
San Francisco,
California
| $1K | -$2.45K | -9 | -82% |
|
|
CA
33
CoreCap Advisors
Southfield,
Michigan
| $1K | +$817 | +3 | New |
|
|
PCM
34
Pentwater Capital Management
Naples,
Florida
| – | -$241K | -1,200 | Closed |
|
35
Morgan Stanley
New York
| – | -$33K | -162 | Closed |
|
|
36
JP Morgan Chase
New York
| – | -$41.9K | -154 | -99% |
|
|
CAM
37
Close Asset Management
London,
United Kingdom
| – | -$37.8K | -139 | -99% |
|
38
Royal Bank of Canada
Toronto,
Ontario, Canada
| – | -$544 | -2 | Closed |
|
|
HR
39
Howe & Rusling
Rochester,
New York
| – | +$544 | +2 | New |
|
LYRA Hedge Fund Activity: Q2 2022 in Review
36 of the 5,937 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q2 2022, worth a combined $109M — up 439% from $20.2M a quarter earlier.
Buyers outnumbered sellers: 14 funds opened new LYRA positions and 4 closed out — a net gain of 10 holders — while 9 added to existing stakes and 8 trimmed.
The largest buyer was Perceptive Advisors, adding an estimated $32.3M. The largest seller was Ikarian Capital, cutting an estimated $408K.
- 36 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q2 2022, up from 26 in Q1 2022.
- Funds reported $109M of LYRA THERAPEUTICS INC stock for Q2 2022, up 439% quarter-over-quarter.
- 14 funds opened new LYRA THERAPEUTICS INC positions in Q2 2022 and 4 closed out, a net change of +10 holders.
- The largest LYRA THERAPEUTICS INC buyer in Q2 2022 was Perceptive Advisors, an estimated $32.3M added.
- The largest LYRA THERAPEUTICS INC seller in Q2 2022 was Ikarian Capital, an estimated $408K sold.
Based on aggregated 13F filings for Q2 2022.