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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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44 hedge funds and large institutions have $55.9M invested in LYRA THERAPEUTICS INC in 2021 Q2 according to their latest regulatory filings, with 11 funds opening new positions, 3 increasing their positions, 21 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

0.09% less ownership

Funds ownership: 1.17% → 1.07% (-0.09%)

10% less funds holding

Funds holding: 49 → 44 (-5)

31% less first-time investments, than exits

New positions opened: 11 | Existing positions closed: 16

36% less capital invested

Capital invested by funds: $87.6M → $55.9M (-$31.7M)

86% less repeat investments, than reductions

Existing positions increased: 3 | Existing positions reduced: 21

Holders
44
Holders Change
-5
Holders Change %
-10.2%
% of All Funds
0.77%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
11
Increased
3
Reduced
21
Closed
16
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
PVI
Pura Vida Investments
New York
+$4.94M
2
Millennium Management
Millennium Management
New York
+$1.41M
3
TEE
Tibra Equities Europe
United Kingdom
+$364K
4
ECM
ExodusPoint Capital Management
New York
+$287K
5
E
Ergoteles
New York
+$282K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$2.99M
2
SCM
Soleus Capital Management
Connecticut
-$2.67M
3
IC
Ikarian Capital
Texas
-$1.42M
4
JP Morgan Chase
JP Morgan Chase
New York
-$1.34M
5
State Street
State Street
Massachusetts
-$1.11M
Name Holding Trade Value Shares
Change 		Change in
Stake
Marshall Wace
26
Marshall Wace
United Kingdom
$155K -$252K -553 -59%
HF
27
HRT Financial
New York
$149K +$169K +372 New
TI
28
Trexquant Investment
Connecticut
$93K +$106K +232 New
Goldman Sachs
29
Goldman Sachs
New York
$86K -$1.82K -4 -2%
Osaic Holdings
30
Osaic Holdings
Arizona
$36K -$347K -761 -90%
TRCT
31
Tower Research Capital (TRC)
New York
$11K +$3.19K +7 +33%
UBS Group
32
UBS Group
Switzerland
$5K -$20K -44 -80%
CCMIC
33
Cardinal Capital Management Inc (Canada)
Manitoba, Canada
$5K – – –
Wells Fargo
34
Wells Fargo
California
$4K -$14.6K -32 -76%
LWANC
35
Laurel Wealth Advisors (North Carolina)
North Carolina
$4K – – –
US Bancorp
36
US Bancorp
Minnesota
$4K – – –
Royal Bank of Canada
37
Royal Bank of Canada
Ontario, Canada
$3K -$16.4K -36 -82%
HI
38
Harbour Investments
Wisconsin
$1K -$10K -22 -85%
Walleye Capital
39
Walleye Capital
New York
$153 +$174K +382 New
JP Morgan Chase
40
JP Morgan Chase
New York
– -$1.34M -2,947 -100%
State Street
41
State Street
Massachusetts
– -$1.11M -1,925 Closed
Northern Trust
42
Northern Trust
Illinois
– -$746K -1,289 Closed
AllianceBernstein
43
AllianceBernstein
Tennessee
– -$711K -1,226 Closed
Envestnet Asset Management
44
Envestnet Asset Management
Illinois
– -$426K -736 Closed
N
45
Nuveen
North Carolina
– -$208K -358 Closed
PPA
46
Parametric Portfolio Associates
Washington
– -$197K -339 Closed
Bank of New York Mellon
47
Bank of New York Mellon
New York
– -$174K -301 Closed
Charles Schwab
48
Charles Schwab
California
– -$165K -284 Closed
Jacobs Levy Equity Management
49
Jacobs Levy Equity Management
New Jersey
– -$143K -247 Closed
California State Teachers Retirement System (CalSTRS)
50
California State Teachers Retirement System (CalSTRS)
California
– -$119K -206 Closed
1
2
3

LYRA Hedge Fund Activity: Q2 2021 in Review

44 of the 5,746 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q2 2021, worth a combined $55.9M — down 36% from $87.6M a quarter earlier.

Sellers outnumbered buyers: 16 funds closed out of LYRA and 11 opened new positions — a net loss of 5 holders — while 21 trimmed existing stakes and 3 added.

The largest buyer was Pura Vida Investments, opening a new position worth an estimated $4.94M. The largest seller was BlackRock, cutting an estimated $2.99M.

  • 44 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q2 2021, down from 49 in Q1 2021.
  • Funds reported $55.9M of LYRA THERAPEUTICS INC stock for Q2 2021, down 36% quarter-over-quarter.
  • 11 funds opened new LYRA THERAPEUTICS INC positions in Q2 2021 and 16 closed out, a net change of -5 holders.
  • The largest LYRA THERAPEUTICS INC buyer in Q2 2021 was Pura Vida Investments, an estimated $4.94M added.
  • The largest LYRA THERAPEUTICS INC seller in Q2 2021 was BlackRock, an estimated $2.99M sold.

Based on aggregated 13F filings for Q2 2021.