State Street’s LYRA THERAPEUTICS INC LYRA Stock Holding History

State Street’s Portfolio LYRA Stock Details LYRA Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q2	–	Sell	-9,774	Closed	-$61.7K	–	4298
2025 Q1	$61.7K	Hold	9,774	–	–	﹤0.01%	4061
2024 Q4	$101K	Hold	9,774	–	–	﹤0.01%	3986
2024 Q3	$126K	Buy	9,774 +4,578	+88%	+$67.2K	﹤0.01%	3932
2024 Q2	$71.9K	Buy	5,196 +2,672	+106%	+$302K	﹤0.01%	4080
2024 Q1	$785K	Buy	2,524 +340	+16%	+$90.6K	﹤0.01%	3530
2023 Q4	$572K	Buy	2,184 +282	+15%	+$51K	﹤0.01%	3615
2023 Q3	$372K	Buy	1,902 +786	+70%	+$141K	﹤0.01%	3735
2023 Q2	$229K	Buy	1,116 +364	+48%	+$50.5K	﹤0.01%	3960
2023 Q1	$77.8K	Hold	752	–	–	﹤0.01%	4395
2022 Q4	$118K	Buy	752 +51	+7%	+$10.1K	﹤0.01%	4320
2022 Q3	$176K	Buy	701 +16	+2%	+$4.73K	﹤0.01%	4209
2022 Q2	$193K	Buy	+685	New	+$186K	﹤0.01%	4211
2021 Q2	–	Sell	-1,925	Closed	-$1.11M	–	4482
2021 Q1	$1.11M	Buy	1,925 +372	+24%	+$232K	﹤0.01%	3600
2020 Q4	$885K	Buy	1,553 +643	+71%	+$362K	﹤0.01%	3576
2020 Q3	$509K	Buy	910 +61	+7%	+$37.9K	﹤0.01%	3571
2020 Q2	$481K	Buy	+849	New	+$621K	﹤0.01%	3545

Other funds holding LYRA

Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return

Sabby Management Miami Beach, Florida $45.1M AUM 74.25% 1-Year Est. Return

Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return

Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return

Ikarian Capital Dallas, Texas $1.23B AUM 600.17% 1-Year Est. Return

Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return

State of Wisconsin Investment Board Madison, Wisconsin $43.7B AUM 27.76% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

State Street's LYRA Position: Q2 2025 in Review

State Street sold out of LYRA THERAPEUTICS INC (LYRA) in Q2 2025, closing a stake of 9,774 shares — an estimated $61.7K sold.

State Street first reported a position in LYRA in Q2 2020 and held it in 16 quarters. The position peaked at $1.11M in Q1 2021. 30 funds tracked by Wall St. Rank hold LYRA as of Q2 2025.

State Street reported no remaining LYRA THERAPEUTICS INC position as of Q2 2025 after selling out during the quarter.
State Street sold 9,774 LYRA THERAPEUTICS INC shares in Q2 2025, an estimated $61.7K.
State Street first reported a position in LYRA THERAPEUTICS INC in Q2 2020 and held it in 16 quarters.
State Street's LYRA THERAPEUTICS INC position peaked at $1.11M in Q1 2021.
30 funds tracked by Wall St. Rank held LYRA THERAPEUTICS INC as of Q2 2025.

Based on State Street's 13F filing for Q2 2025, filed 14 Aug 2025.