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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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49 hedge funds and large institutions have $87.6M invested in LYRA THERAPEUTICS INC in 2021 Q1 according to their latest regulatory filings, with 10 funds opening new positions, 13 increasing their positions, 13 reducing their positions, and 4 closing their positions.

New
Increased
Maintained
Reduced
Closed

150% more first-time investments, than exits

New positions opened: 10 | Existing positions closed: 4

14% more funds holding

Funds holding: 43 → 49 (+6)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

0% more repeat investments, than reductions

Existing positions increased: 13 | Existing positions reduced: 13

0.16% less ownership

Funds ownership: 1.33% → 1.17% (-0.16%)

11% less capital invested

Capital invested by funds: $97.9M → $87.6M (-$10.4M)

Holders
49
Holders Change
+6
Holders Change %
+13.95%
% of All Funds
0.86%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.02%
New
10
Increased
13
Reduced
13
Closed
4
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
+$1.16M
2
BlackRock
BlackRock
New York
+$1.05M
3
Deutsche Bank
Deutsche Bank
Germany
+$950K
4
William Blair & Company
William Blair & Company
Illinois
+$687K
5
Two Sigma Investments
Two Sigma Investments
New York
+$619K

Top Sellers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
-$9.3M
2
ACH
ArrowMark Colorado Holdings
Colorado
-$7.96M
3
AAA
Affinity Asset Advisors
New York
-$570K
4
JP Morgan Chase
JP Morgan Chase
New York
-$545K
5
Millennium Management
Millennium Management
New York
-$502K
Name Holding Trade Value Shares
Change 		Change in
Stake
N
26
Nuveen
North Carolina
$208K +$224K +358 New
PPA
27
Parametric Portfolio Associates
Washington
$197K -$243K -389 -53%
Bank of New York Mellon
28
Bank of New York Mellon
New York
$174K -$55K -88 -23%
Charles Schwab
29
Charles Schwab
California
$165K – – –
Jacobs Levy Equity Management
30
Jacobs Levy Equity Management
New Jersey
$143K +$1.25K +2 +0.8%
Goldman Sachs
31
Goldman Sachs
New York
$127K +$1.25K +2 +0.9%
California State Teachers Retirement System (CalSTRS)
32
California State Teachers Retirement System (CalSTRS)
California
$119K – – –
New York State Common Retirement Fund
33
New York State Common Retirement Fund
New York
$51K – – –
UBS Group
34
UBS Group
Switzerland
$32K -$10.6K -17 -24%
Royal Bank of Canada
35
Royal Bank of Canada
Ontario, Canada
$25K -$1.87K -3 -6%
Wells Fargo
36
Wells Fargo
California
$24K -$17.5K -28 -40%
HI
37
Harbour Investments
Wisconsin
$15K +$16.2K +26 New
TRCT
38
Tower Research Capital (TRC)
New York
$13K -$10.6K -17 -45%
SO
39
STRS Ohio
Ohio
$12K – – –
Legal & General Group
40
Legal & General Group
United Kingdom
$9K – – –
Citigroup
41
Citigroup
New York
$8K -$7.5K -12 -48%
CCMIC
42
Cardinal Capital Management Inc (Canada)
Manitoba, Canada
$8K +$8.12K +13 New
LWANC
43
Laurel Wealth Advisors (North Carolina)
North Carolina
$6K +$6.25K +10 New
US Bancorp
44
US Bancorp
Minnesota
$6K +$6.25K +10 New
AIP
45
Ameritas Investment Partners
Nebraska
$4K – – –
Bank of Montreal
46
Bank of Montreal
Ontario, Canada
$2K -$11.9K -19 -83%
SBL
47
Sargent Bickham Lagudis
Colorado
$1K +$1.25K +2 New
TFA
48
Toth Financial Advisory
Virginia
$1K +$1.25K +2 New
AIG
49
American International Group
New York
$46 – – –
RCM
50
RA Capital Management
Massachusetts
– -$9.3M -16,317 Closed
1
2
3

LYRA Hedge Fund Activity: Q1 2021 in Review

49 of the 5,696 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q1 2021, worth a combined $87.6M — down 11% from $97.9M a quarter earlier.

Buyers outnumbered sellers: 10 funds opened new LYRA positions and 4 closed out — a net gain of 6 holders — while 13 added to existing stakes and 13 trimmed.

The largest buyer was Morgan Stanley, adding an estimated $1.16M. The largest seller was RA Capital Management, exiting entirely with an estimated $9.3M sold.

  • 49 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q1 2021, up from 43 in Q4 2020.
  • Funds reported $87.6M of LYRA THERAPEUTICS INC stock for Q1 2021, down 11% quarter-over-quarter.
  • 10 funds opened new LYRA THERAPEUTICS INC positions in Q1 2021 and 4 closed out, a net change of +6 holders.
  • The largest LYRA THERAPEUTICS INC buyer in Q1 2021 was Morgan Stanley, an estimated $1.16M added.
  • The largest LYRA THERAPEUTICS INC seller in Q1 2021 was RA Capital Management, an estimated $9.3M sold.

Based on aggregated 13F filings for Q1 2021.