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Disc Medicine

151 hedge funds and large institutions have $1.8B invested in Disc Medicine in 2025 Q2 according to their latest regulatory filings, with 26 funds opening new positions, 69 increasing their positions, 36 reducing their positions, and 31 closing their positions.

New
Increased
Maintained
Reduced
Closed

2,002% more call options, than puts

Call options by funds: $23.4M | Put options by funds: $1.11M

92% more repeat investments, than reductions

Existing positions increased: 69 | Existing positions reduced: 36

13% more funds holding in top 10

Funds holding in top 10: 89 (+1)

9% more capital invested

Capital invested by funds: $1.65B → $1.8B (+$155M)

2.46% more ownership

Funds ownership: 95.9%98.37% (+2.5%)

4% less funds holding

Funds holding: 157151 (-6)

16% less first-time investments, than exits

New positions opened: 26 | Existing positions closed: 31

Holders
151
Holders Change
-6
Holders Change %
-3.82%
% of All Funds
1.99%
Holding in Top 10
9
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+12.5%
% of All Funds
0.12%
New
26
Increased
69
Reduced
36
Closed
31
Calls
$23.4M
Puts
$1.11M
Net Calls
+$22.3M
Net Calls Change
+$21M
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$172M +$1M +21,329 +0.7%
AVLSA
2
Atlas Venture Life Science Advisors
Massachusetts
$126M
BlackRock
3
BlackRock
New York
$108M -$2.34M -49,733 -2%
FLSM
4
Frazier Life Sciences Management
California
$87.6M -$4.7M -100,000 -6%
RCM
5
RA Capital Management
Massachusetts
$83.5M
Janus Henderson Group
6
Janus Henderson Group
United Kingdom
$82.3M +$6.14M +130,702 +9%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$80.3M +$7.39M +157,371 +12%
Wellington Management Group
8
Wellington Management Group
Massachusetts
$75.8M -$42.8M -911,409 -39%
O
9
OrbiMed
New York
$74.9M
Vanguard Group
10
Vanguard Group
Pennsylvania
$74M +$4.31M +91,690 +7%
PBA
11
Paradigm Biocapital Advisors
New York
$64.1M
SL
12
Siren LLC
Connecticut
$58.2M +$1.29M +27,536 +3%
State Street
13
State Street
Massachusetts
$49.2M +$526K +11,201 +1%
DM
14
Deerfield Management
New York
$48.7M +$6.44M +137,070 +18%
WP
15
Woodline Partners
California
$45.9M +$17.1M +364,725 +73%
JP Morgan Chase
16
JP Morgan Chase
New York
$44.7M +$3.96M +84,278 +11%
LGM
17
Logos Global Management
California
$37.1M +$14.4M +305,658 +78%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$31.7M +$1.25M +26,605 +5%
BCLSI
19
Bain Capital Life Sciences Investors
Massachusetts
$30.9M -$18.8M -400,000 -41%
TCM
20
TCG Crossover Management
California
$24.6M
Adage Capital Partners
21
Adage Capital Partners
Massachusetts
$23.8M +$7.05M +150,000 +50%
AC
22
Armistice Capital
New York
$23.1M
SVCM
23
Saturn V Capital Management
Texas
$21M -$5.73M -122,062 -24%
BBA
24
Baker Bros. Advisors
New York
$17.9M +$12.2M +260,000 +337%
EAM
25
Eventide Asset Management
Massachusetts
$16.3M +$5.93M +126,212 +69%

IRON Hedge Fund Activity: Q2 2025 in Review

151 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Disc Medicine (IRON) for Q2 2025, worth a combined $1.8B — up 9.4% from $1.65B a quarter earlier.

Sellers outnumbered buyers: 31 funds closed out of IRON and 26 opened new positions — a net loss of 5 holders — while 36 trimmed existing stakes and 69 added.

The largest buyer was Woodline Partners, adding an estimated $17.1M. The largest seller was Wellington Management Group, cutting an estimated $42.8M.

  • 151 institutional investors held Disc Medicine (IRON) as of Q2 2025, down from 157 in Q1 2025.
  • Funds reported $1.8B of Disc Medicine stock for Q2 2025, up 9.4% quarter-over-quarter.
  • 26 funds opened new Disc Medicine positions in Q2 2025 and 31 closed out, a net change of -5 holders.
  • The largest Disc Medicine buyer in Q2 2025 was Woodline Partners, an estimated $17.1M added.
  • The largest Disc Medicine seller in Q2 2025 was Wellington Management Group, an estimated $42.8M sold.

Based on aggregated 13F filings for Q2 2025.