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Disc Medicine
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Overview Fund Activity

150 hedge funds and large institutions have $1.8B invested in Disc Medicine in 2025 Q2 according to their latest regulatory filings, with 25 funds opening new positions, 69 increasing their positions, 36 reducing their positions, and 31 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
150
Holders Change
-7
Holders Change %
-4.46%
% of All Funds
2.01%
Holding in Top 10
9
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+12.5%
% of All Funds
0.12%
New
25
Increased
69
Reduced
36
Closed
31
Calls
$23.4M
Puts
$1.11M
Net Calls
+$22.3M
Net Calls Change
+$21M

Top Buyers

1
WP
Woodline Partners
California
$45.9M
2
LGM
Logos Global Management
California
$37.1M
3
FTM
First Turn Management
California
$15.9M
4
BBA
Baker Bros. Advisors
New York
$17.9M
5
SCM
Sio Capital Management
New York
$15.1M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
$75.8M
2
BCLSI
Bain Capital Life Sciences Investors
Massachusetts
$30.9M
3
SCM
Silverarc Capital Management
Massachusetts
$0
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
$0
5
PA
Perceptive Advisors
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$172M +$1.13M +21,329 +0.7%
AVLSA
2
Atlas Venture Life Science Advisors
Massachusetts
$126M – – –
BlackRock
3
BlackRock
New York
$108M -$2.63M -49,733 -2%
FLSM
4
Frazier Life Sciences Management
California
$87.6M -$5.3M -100,000 -6%
RCM
5
RA Capital Management
Massachusetts
$83.5M – – –
Janus Henderson Group
6
Janus Henderson Group
United Kingdom
$82.3M +$6.92M +130,702 +9%
T. Rowe Price Associates
7
T. Rowe Price Associates
Maryland
$80.3M +$8.33M +157,371 +12%
Wellington Management Group
8
Wellington Management Group
Massachusetts
$75.8M -$48.3M -911,409 -39%
O
9
OrbiMed
New York
$74.9M – – –
Vanguard Group
10
Vanguard Group
Pennsylvania
$74M +$4.86M +91,690 +7%
PBA
11
Paradigm Biocapital Advisors
New York
$64.1M – – –
SL
12
Siren LLC
Connecticut
$58.2M +$1.46M +27,536 +3%
State Street
13
State Street
Massachusetts
$49.2M +$593K +11,201 +1%
DM
14
Deerfield Management
New York
$48.7M +$7.26M +137,070 +18%
WP
15
Woodline Partners
California
$45.9M +$19.3M +364,725 +73%
JPMorgan Chase & Co
16
JPMorgan Chase & Co
New York
$44.7M +$4.46M +84,278 +11%
LGM
17
Logos Global Management
California
$37.1M +$16.2M +305,658 +78%
Geode Capital Management
18
Geode Capital Management
Massachusetts
$31.7M +$1.41M +26,605 +5%
BCLSI
19
Bain Capital Life Sciences Investors
Massachusetts
$30.9M -$21.2M -400,000 -41%
TCM
20
TCG Crossover Management
California
$24.6M – – –
Adage Capital Partners
21
Adage Capital Partners
Massachusetts
$23.8M +$7.94M +150,000 +50%
AC
22
Armistice Capital
New York
$23.1M – – –
SVCM
23
Saturn V Capital Management
Texas
$21M -$6.46M -122,062 -24%
BBA
24
Baker Bros. Advisors
New York
$17.9M +$13.8M +260,000 +337%
EAM
25
Eventide Asset Management
Massachusetts
$16.3M +$6.68M +126,212 +69%
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