|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$358M
|
-$47.6M
|
-692,421
|
-12%
|
|
|
2
|
|
$181M
|
+$13.3M
|
+194,068
|
+9%
|
|
|
3
|
RA Capital Management
Boston,
Massachusetts
|
$179M
|
–
|
–
|
–
|
|
|
4
|
|
$140M
|
+$34.7M
|
+504,315
|
+37%
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$137M
|
+$22.4M
|
+326,049
|
+21%
|
|
|
6
|
Wellington Management Group
Boston,
Massachusetts
|
$127M
|
+$411K
|
+5,975
|
+0.3%
|
|
|
7
|
State Street
Boston,
Massachusetts
|
$121M
|
-$3.4M
|
-49,408
|
-3%
|
|
|
8
|
Vestal Point Capital
New York
|
$113M
|
+$58.4M
|
+850,000
|
+121%
|
|
|
9
|
Atlas Venture Life Science Advisors
Cambridge,
Massachusetts
|
$111M
|
–
|
–
|
–
|
|
|
10
|
Vanguard Capital Management
Malvern,
Pennsylvania
|
$100M
|
-$440K
|
-6,403
|
-0.5%
|
|
|
11
|
Frazier Life Sciences Management
Palo Alto,
California
|
$99.1M
|
–
|
–
|
–
|
|
|
12
|
TCG Crossover Management
Palo Alto,
California
|
$98.1M
|
–
|
–
|
–
|
|
|
13
|
BVF Inc
San Francisco,
California
|
$84.4M
|
-$8.16M
|
-118,700
|
-9%
|
|
|
14
|
Woodline Partners
San Francisco,
California
|
$70.1M
|
–
|
–
|
–
|
|
|
15
|
Siren LLC
Greenwich,
Connecticut
|
$65M
|
-$6.87M
|
-100,000
|
-10%
|
|
|
16
|
Logos Global Management
San Francisco,
California
|
$64M
|
+$21.6M
|
+315,000
|
+56%
|
|
|
17
|
Opaleye Management
Boston,
Massachusetts
|
$62.5M
|
+$29.8M
|
+434,000
|
+103%
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
$57.8M
|
+$3.13M
|
+45,502
|
+6%
|
|
|
19
|
Deerfield Management
New York
|
$48.1M
|
–
|
–
|
–
|
|
|
20
|
Dimensional Fund Advisors
Austin,
Texas
|
$41.6M
|
+$12M
|
+174,571
|
+44%
|
|
|
21
|
Bellevue Group
Kuesnacht,
Switzerland
|
$41M
|
+$6.92M
|
+100,686
|
+22%
|
|
|
22
|
Saturn V Capital Management
Austin,
Texas
|
$38.4M
|
+$5.14M
|
+74,804
|
+17%
|
|
|
23
|
Armistice Capital
New York
|
$33.6M
|
-$5.22M
|
-76,000
|
-14%
|
|
|
24
|
Jennison Associates
New York
|
$32.1M
|
-$11.7M
|
-170,862
|
-28%
|
|
|
25
|
Aberdeen Group
Edinburgh,
United Kingdom
|
$32M
|
+$4.3M
|
+62,560
|
+17%
|
|
