Two Sigma Investments’s Disc Medicine IRON Stock Holding History

Two Sigma Investments’s Portfolio IRON Stock Details IRON Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2026 Q2	$10M	Buy	+136,750	New	+$9.4M	0.01%	1525
2024 Q2	–	Sell	-14,711	Closed	-$916K	–	3176
2024 Q1	$916K	Sell	14,711 -8,383	-36%	-$544K	﹤0.01%	2003
2023 Q4	$1.33M	Buy	23,094 +13,794	+148%	+$706K	﹤0.01%	1898
2023 Q3	$437K	Sell	9,300 -30,961	-77%	-$1.55M	﹤0.01%	2334
2023 Q2	$1.79M	Buy	40,261 +16,111	+67%	+$572K	﹤0.01%	1514
2023 Q1	$512K	Buy	+24,150	New	+$538K	﹤0.01%	2192
2021 Q4	–	Sell	-1,316	Closed	-$160K	–	4556
2021 Q3	$160K	Buy	1,316 +839	+176%	+$115K	﹤0.01%	4011
2021 Q2	$93K	Buy	+477	New	+$157K	﹤0.01%	3907

Other funds holding IRON

Fidelity Investments Boston, Massachusetts $2.3T AUM 54.33% 1-Year Est. Return

BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return

RCM

RA Capital Management Boston, Massachusetts $11.5B AUM 168.77% 1-Year Est. Return

JP Morgan Chase New York $1.81T AUM 41.13% 1-Year Est. Return

T. Rowe Price Associates Baltimore, Maryland $999B AUM 46.22% 1-Year Est. Return

Wellington Management Group Boston, Massachusetts $580B AUM 38.23% 1-Year Est. Return

State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

VPC

Vestal Point Capital New York $4.28B AUM 239% 1-Year Est. Return

AVLSA

Atlas Venture Life Science Advisors Cambridge, Massachusetts $881M AUM 160.77% 1-Year Est. Return

Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM

Two Sigma Investments's IRON Position: Q2 2026 in Review

Two Sigma Investments opened a new position in Disc Medicine (IRON) in Q2 2026: 136,750 shares worth $10M. The stake represents 0.01% of the portfolio and ranks #1525 among its holdings. This is a return to the name: Two Sigma Investments previously reported a position in IRON as recently as Q1 2024.

Two Sigma Investments first reported a position in IRON in Q2 2021 and has held it in 8 quarters since. 216 funds tracked by Wall St. Rank hold IRON as of Q2 2026.

Two Sigma Investments held 136,750 shares of Disc Medicine worth $10M as of Q2 2026.
Disc Medicine was a new Two Sigma Investments position in Q2 2026.
Disc Medicine made up 0.01% of Two Sigma Investments's portfolio in Q2 2026, its #1525 holding.
Two Sigma Investments first reported a position in Disc Medicine in Q2 2021 and has held it in 8 quarters since.
216 funds tracked by Wall St. Rank held Disc Medicine as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.