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Disc Medicine

196 hedge funds and large institutions have $3.04B invested in Disc Medicine in 2025 Q4 according to their latest regulatory filings, with 42 funds opening new positions, 86 increasing their positions, 48 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

250% more first-time investments, than exits

New positions opened: 42 | Existing positions closed: 12

79% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 48

57% more funds holding in top 10

Funds holding in top 10: 711 (+4)

35% more capital invested

Capital invested by funds: $2.26B → $3.04B (+$782M)

17% more funds holding

Funds holding: 168196 (+28)

3% more ownership

Funds ownership: 98.43%101.43% (+3%)

71% less call options, than puts

Call options by funds: $2.76M | Put options by funds: $9.43M

Holders
196
Holders Change
+28
Holders Change %
+16.67%
% of All Funds
2.38%
Holding in Top 10
11
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+57.14%
% of All Funds
0.13%
New
42
Increased
86
Reduced
48
Closed
12
Calls
$2.76M
Puts
$9.43M
Net Calls
-$6.66M
Net Calls Change
-$8.87M
Name Holding Trade Value Shares
Change
Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$433M +$43.5M +515,063 +10%
BlackRock
2
BlackRock
New York
$181M +$21.6M +255,697 +13%
RCM
3
RA Capital Management
Massachusetts
$157M +$33.7M +399,026 +25%
Vanguard Group
4
Vanguard Group
Pennsylvania
$140M +$27M +319,621 +22%
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$135M +$31.4M +371,576 +28%
JP Morgan Chase
6
JP Morgan Chase
New York
$126M +$70M +828,248 +110%
Wellington Management Group
7
Wellington Management Group
Massachusetts
$121M +$9.14M +108,197 +8%
AVLSA
8
Atlas Venture Life Science Advisors
Massachusetts
$120M -$53.1M -628,742 -29%
FLSM
9
Frazier Life Sciences Management
California
$100M -$15.1M -178,534 -12%
State Street
10
State Street
Massachusetts
$94.3M +$12M +142,394 +14%
O
11
OrbiMed
New York
$84.8M -$29.4M -347,470 -25%
SL
12
Siren LLC
Connecticut
$78.5M +$6.34M +75,000 +8%
WP
13
Woodline Partners
California
$76.1M +$7.68M +90,878 +10%
Goldman Sachs
14
Goldman Sachs
New York
$59.9M +$19M +225,114 +43%
VPC
15
Vestal Point Capital
New York
$58.4M +$19.9M +235,000 +47%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$54.4M +$4.8M +56,807 +9%
BI
17
BVF Inc
California
$51.6M +$54.9M +650,000 New
Jennison Associates
18
Jennison Associates
New York
$42.3M +$45M +532,079 New
FLAM
19
First Light Asset Management
Minnesota
$41.5M +$24.7M +291,981 +126%
DM
20
Deerfield Management
New York
$40.6M -$34.5M -408,240 -44%
LGM
21
Logos Global Management
California
$40.5M +$5.07M +60,000 +13%
AC
22
Armistice Capital
New York
$39.7M +$5.36M +63,391 +15%
CC
23
Checkpoint Capital
California
$36M +$1.94M +22,992 +5%
PA
24
Perceptive Advisors
New York
$35.8M +$38.1M +450,743 New
EAM
25
Eventide Asset Management
Massachusetts
$31.4M +$7.38M +87,349 +28%