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Ionis Pharmaceuticals
IONS

Overview Fund Activity

358 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 107 reducing their positions, and 57 closing their positions.

Holders
358
Holders Change
+19
Holders Change %
+5.6%
% of All Funds
4.81%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
107
Closed
57
Calls
$48.1M
Puts
$26.1M
Net Calls
+$22M
Net Calls Change
+$16M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Market Value Shares Shares
Change 		Shares
Change %
RBI
126
Raiffeisen Bank International
Austria
$2.27M 56,754 +15,000 +36%
First Trust Advisors
127
First Trust Advisors
Illinois
$2.23M 56,519 +56,519 New
PP
128
PDT Partners
New York
$2.15M 54,365 -41,691 -43%
Ensign Peak Advisors
129
Ensign Peak Advisors
Utah
$2.11M 53,320 -1,780 -3%
Creative Planning
130
Creative Planning
Kansas
$2.11M 53,289 +17,167 +48%
AllianceBernstein
131
AllianceBernstein
Tennessee
$2.06M 52,057 -48,692 -48%
EAM
132
Erste Asset Management
Austria
$2.04M 51,300 – –
CC
133
Capital Counsel
New York
$1.98M 50,205 +13,125 +35%
Ohio Public Employees Retirement System (OPERS)
134
Ohio Public Employees Retirement System (OPERS)
Ohio
$1.91M 48,244 +67 +0.1%
Canada Life
135
Canada Life
Manitoba, Canada
$1.84M 46,501 +2,648 +6%
ASRS
136
Arizona State Retirement System
Arizona
$1.74M 44,040 +3,353 +8%
Zurich Cantonal Bank
137
Zurich Cantonal Bank
Switzerland
$1.72M 43,615 +7,106 +19%
Handelsbanken Fonder
138
Handelsbanken Fonder
Sweden
$1.71M 43,211 – –
GIP
139
Granite Investment Partners
California
$1.71M 43,181 -25,253 -37%
NSEDCP
140
NJ State Employees Deferred Compensation Plan
New Jersey
$1.66M 42,000 – –
GC
141
Guggenheim Capital
Illinois
$1.61M 40,857 -557 -1%
Simplex Trading
142
Simplex Trading
Illinois
$1.57M 39,638 -24,943 -39%
PCM
143
Prelude Capital Management
New York
$1.56M 39,423 +1,651 +4%
AG
144
Algert Global
California
$1.51M 38,090 +38,090 New
William Blair & Company
145
William Blair & Company
Illinois
$1.5M 37,891 -490 -1%
YIH
146
Y-Intercept (HK)
Hong Kong
$1.49M 37,649 +37,649 New
GD
147
Grandfield & Dodd
New York
$1.47M 37,230 -531 -1%
Mariner
148
Mariner
Kansas
$1.46M 36,914 +3,431 +10%
EGM
149
Engineers Gate Manager
New York
$1.31M 33,118 +33,118 New
BHCM
150
Brevan Howard Capital Management
Jersey
$1.29M 32,732 +9,759 +42%
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