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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$108M
2
Millennium Management
Millennium Management
New York
+$79.6M
3
PCH
Polar Capital Holdings
United Kingdom
+$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$30.4M
5
WP
Woodline Partners
California
+$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
-$81.8M
2
Citadel Advisors
Citadel Advisors
Florida
-$78.4M
3
O
OrbiMed
New York
-$76.6M
4
Invesco
Invesco
Georgia
-$24.4M
5
CCM
Camber Capital Management
Massachusetts
-$21.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$934M +$1.16M +29,405 +0.1%
Vanguard Group
2
Vanguard Group
Pennsylvania
$660M +$13.1M +330,912 +2%
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$634M -$5.01M -126,812 -0.8%
Capital World Investors
4
Capital World Investors
California
$495M +$7.04M +178,194 +1%
BlackRock
5
BlackRock
New York
$431M -$14.5M -367,505 -3%
BG
6
Bellevue Group
Switzerland
$310M – – –
Wellington Management Group
7
Wellington Management Group
Massachusetts
$251M -$81.8M -2,070,645 -25%
DTC
8
Deep Track Capital
Connecticut
$193M +$12.9M +327,337 +7%
State Street
9
State Street
Massachusetts
$179M -$12.4M -314,735 -6%
Adage Capital Partners
10
Adage Capital Partners
Massachusetts
$150M +$108M +2,724,400 +253%
T. Rowe Price Associates
11
T. Rowe Price Associates
Maryland
$124M -$5.49M -138,961 -4%
TBC
12
Tweedy, Browne Co
Connecticut
$114M -$3.62M -91,570 -3%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$114M +$1.9M +48,141 +2%
Two Sigma Advisers
14
Two Sigma Advisers
New York
$105M +$22.7M +575,600 +28%
Millennium Management
15
Millennium Management
New York
$105M +$79.6M +2,014,157 +317%
BI
16
BVF Inc
California
$75.6M – – –
Two Sigma Investments
17
Two Sigma Investments
New York
$70.7M +$4.05M +102,514 +6%
UBS Group
18
UBS Group
Switzerland
$60.4M -$14.3M -361,279 -19%
Citadel Advisors
19
Citadel Advisors
Florida
$59.1M -$78.4M -1,985,081 -57%
Charles Schwab
20
Charles Schwab
California
$58.8M +$1.75M +44,189 +3%
Macquarie Group
21
Macquarie Group
Australia
$56.7M -$9.21M -233,121 -14%
Morgan Stanley
22
Morgan Stanley
New York
$53.8M +$8.61M +218,028 +19%
BNP Paribas Asset Management
23
BNP Paribas Asset Management
France
$53.4M +$6.1M +154,487 +13%
TD Asset Management
24
TD Asset Management
Ontario, Canada
$43.6M +$167K +4,224 +0.4%
PCH
25
Polar Capital Holdings
United Kingdom
$39.5M +$39.5M +1,000,000 New
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