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Ionis Pharmaceuticals
IONS

Overview Fund Activity

358 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 107 reducing their positions, and 57 closing their positions.

Holders
358
Holders Change
+19
Holders Change %
+5.6%
% of All Funds
4.81%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
107
Closed
57
Calls
$48.1M
Puts
$26.1M
Net Calls
+$22M
Net Calls Change
+$16M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Fidelity Investments
1
Fidelity Investments
Massachusetts
$934M 23,642,990 +29,405 +0.1%
Vanguard Group
2
Vanguard Group
Pennsylvania
$660M 16,714,846 +330,912 +2%
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$634M 16,048,721 -126,812 -0.8%
Capital World Investors
4
Capital World Investors
California
$495M 12,540,188 +178,194 +1%
BlackRock
5
BlackRock
New York
$431M 10,896,937 -367,505 -3%
BG
6
Bellevue Group
Switzerland
$310M 7,853,198 – –
Wellington Management Group
7
Wellington Management Group
Massachusetts
$251M 6,345,776 -2,070,645 -25%
DTC
8
Deep Track Capital
Connecticut
$193M 4,891,544 +327,337 +7%
State Street
9
State Street
Massachusetts
$179M 4,530,398 -314,735 -6%
Adage Capital Partners
10
Adage Capital Partners
Massachusetts
$150M 3,800,000 +2,724,400 +253%
T. Rowe Price Associates
11
T. Rowe Price Associates
Maryland
$124M 3,126,073 -138,961 -4%
TBC
12
Tweedy, Browne Co
Connecticut
$114M 2,891,948 -91,570 -3%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$114M 2,891,095 +48,141 +2%
Two Sigma Advisers
14
Two Sigma Advisers
New York
$105M 2,667,611 +575,600 +28%
Millennium Management
15
Millennium Management
New York
$105M 2,649,527 +2,014,157 +317%
BI
16
BVF Inc
California
$75.6M 1,913,385 – –
Two Sigma Investments
17
Two Sigma Investments
New York
$70.7M 1,788,367 +102,514 +6%
UBS Group
18
UBS Group
Switzerland
$60.4M 1,529,323 -361,279 -19%
Citadel Advisors
19
Citadel Advisors
Florida
$59.1M 1,494,981 -1,985,081 -57%
Charles Schwab
20
Charles Schwab
California
$58.8M 1,487,818 +44,189 +3%
Macquarie Group
21
Macquarie Group
Australia
$56.7M 1,434,073 -233,121 -14%
Morgan Stanley
22
Morgan Stanley
New York
$53.8M 1,362,209 +218,028 +19%
BNP Paribas Asset Management
23
BNP Paribas Asset Management
France
$53.4M 1,350,879 +154,487 +13%
TD Asset Management
24
TD Asset Management
Ontario, Canada
$43.6M 1,104,690 +4,224 +0.4%
PCH
25
Polar Capital Holdings
United Kingdom
$39.5M 1,000,000 +1,000,000 New
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