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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
Millennium Management
New York
$105M
3
PCH
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
$30.4M
5
WP
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
Citadel Advisors
Florida
$59.1M
3
O
OrbiMed
New York
$0
4
Invesco
Invesco
Georgia
$10.1M
5
CCM
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
BHCM
151
Brevan Howard Capital Management
Jersey
$1.29M +$386K +9,759 +42%
Nomura Holdings
152
Nomura Holdings
Japan
$1.27M -$8.07M -204,265 -86%
CUAMC
153
China Universal Asset Management Company
China
$1.26M +$3.16K +80 +0.3%
KK
154
KLP Kapitalforvaltning
Norway
$1.24M +$162K +4,100 +15%
Capital Fund Management (CFM)
155
Capital Fund Management (CFM)
France
$1.23M -$1.06M -26,795 -46%
Pathstone Holdings
156
Pathstone Holdings
New Jersey
$1.22M -$143K -3,613 -11%
OCM
157
One Capital Management
California
$1.18M +$1.18M +29,865 New
FFL
158
Future Fund LLC
Illinois
$1.17M +$1.17M +29,595 New
ET
159
Entropy Technologies
New York
$1.16M +$1.16M +29,452 New
PA
160
Profund Advisors
Maryland
$1.14M -$238K -6,028 -17%
NIM
161
NEOS Investment Management
Connecticut
$1.11M +$119K +3,020 +12%
TE
162
Tema ETFs
New York
$1.11M +$119K +3,020 +12%
Daiwa Securities Group
163
Daiwa Securities Group
Japan
$1.03M +$158K +4,000 +18%
AGM
164
Alpine Global Management
New York
$1.01M -$105K -2,660 -9%
LPL Financial
165
LPL Financial
California
$983K +$35.8K +906 +4%
TRSOTSOK
166
Teachers Retirement System of the State of Kentucky
Kentucky
$952K – – –
X
167
Xponance
Pennsylvania
$899K +$96.2K +2,435 +12%
OAM
168
Oxford Asset Management
United Kingdom
$885K +$885K +22,405 New
JFG
169
Jefferies Financial Group
New York
$884K -$18.2K -460 -2%
GCM
170
Graham Capital Management
Connecticut
$827K +$827K +20,935 New
NIM
171
Nicollet Investment Management
Minnesota
$820K -$27.8K -704 -3%
Victory Capital Management
172
Victory Capital Management
Texas
$732K -$4.94K -125 -0.7%
BFG
173
Bleakley Financial Group
New Jersey
$716K -$164K -4,155 -19%
Assenagon Asset Management
174
Assenagon Asset Management
Luxembourg
$698K +$698K +17,654 New
QCM
175
Quantinno Capital Management
New York
$693K +$357K +9,027 +106%
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