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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
FCM
176
Fieldview Capital Management
Michigan
$684K +$684K +17,306 New
SC
177
SummitTX Capital
Texas
$678K -$709K -17,954 -51%
NSAM
178
North Star Asset Management
Wisconsin
$656K +$119K +3,000 +22%
BCM
179
Bayesian Capital Management
New York
$656K +$320K +8,100 +95%
EFM
180
E Fund Management
China
$638K -$12.3K -311 -2%
Public Employees Retirement Association of Colorado
181
Public Employees Retirement Association of Colorado
Colorado
$616K – – –
SWP
182
Significant Wealth Partners
Illinois
$613K +$75K +1,899 +14%
LWANC
183
Laurel Wealth Advisors (North Carolina)
North Carolina
$600K +$585K +23,106 +3,851%
CC
184
Corton Capital
Ontario, Canada
$570K +$570K +14,424 New
VAS
185
Vestmark Advisory Solutions
Massachusetts
$567K +$567K +14,341 New
GAM
186
Gotham Asset Management
New York
$564K +$564K +14,279 New
Commonwealth Equity Services
187
Commonwealth Equity Services
Massachusetts
$551K -$97.1K -2,456 -15%
Envestnet Asset Management
188
Envestnet Asset Management
Illinois
$535K -$59.1K -1,495 -10%
IEFM
189
IQ EQ Fund Management
Ireland
$524K +$206K +5,204 +65%
Marshall Wace
190
Marshall Wace
United Kingdom
$518K +$158K +3,998 +44%
WP
191
Westmount Partners
California
$512K – – –
AGWCA
192
Annis Gardner Whiting Capital Advisors
Florida
$506K +$81.6K +2,065 +19%
PP
193
Paloma Partners
Connecticut
$496K +$496K +12,557 New
VIA
194
Virtus Investment Advisers
Connecticut
$493K +$110K +2,775 +29%
DnB Asset Management
195
DnB Asset Management
Norway
$485K +$485K +12,271 New
Northwestern Mutual Wealth Management
196
Northwestern Mutual Wealth Management
Wisconsin
$484K -$4.5K -114 -0.9%
Brown Advisory
197
Brown Advisory
Maryland
$482K +$6.52K +165 +1%
VPIM
198
Vanguard Personalized Indexing Management
California
$477K +$69.5K +1,759 +17%
VA
199
Vident Advisory
Georgia
$474K +$474K +12,000 New
HKAM
200
Horizon Kinetics Asset Management
New York
$472K -$20.7K -524 -4%
6 7
8
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