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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Qube Research & Technologies (QRT)
176
Qube Research & Technologies (QRT)
United Kingdom
$3.22M
ASRS
177
Arizona State Retirement System
Arizona
$3.17M
TAM
178
TFG Asset Management
Cayman Islands
$3.14M
SLG
179
Stanley-Laman Group
Pennsylvania
$2.95M
AIP
180
Arrowpoint Investment Partners
Singapore
$2.93M
VIA
181
Vanguard Investments Australia
Australia
$2.9M
IIM
182
INTECH Investment Management
Florida
$2.89M
GD
183
Grandfield & Dodd
New York
$2.8M
Prudential Financial
184
Prudential Financial
New Jersey
$2.65M
BBA
185
BLB&B Advisors
Pennsylvania
$2.64M
RBI
186
Raiffeisen Bank International
Austria
$2.61M
VanEck Associates
187
VanEck Associates
New York
$2.59M
PEAK6
188
PEAK6
Illinois
$2.58M
ETC
189
Exchange Traded Concepts
Oklahoma
$2.55M
KK
190
KLP Kapitalforvaltning
Norway
$2.55M
William Blair & Company
191
William Blair & Company
Illinois
$2.54M
Assenagon Asset Management
192
Assenagon Asset Management
Luxembourg
$2.53M
TI
193
Tidal Investments
Wisconsin
$2.51M
Pathstone Holdings
194
Pathstone Holdings
New Jersey
$2.47M
Swedbank
195
Swedbank
Sweden
$2.42M
LPL Financial
196
LPL Financial
California
$2.4M
KBC Group
197
KBC Group
Belgium
$2.27M
PCM
198
Prelude Capital Management
New York
$2.23M
KCM
199
Kornitzer Capital Management
Kansas
$2.19M
AQR Capital Management
200
AQR Capital Management
Connecticut
$2.16M