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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
LCM
226
Landscape Capital Management
New Jersey
$1.51M
LCM
227
Legato Capital Management
California
$1.49M
Calamos Advisors
228
Calamos Advisors
Illinois
$1.49M
FC
229
FORA Capital
Florida
$1.48M
NIM
230
Nicollet Investment Management
Minnesota
$1.48M
AA
231
AlphaCentric Advisors
Puerto Rico
$1.47M
DnB Asset Management
232
DnB Asset Management
Norway
$1.43M
DIA
233
Dana Investment Advisors
Wisconsin
$1.39M
I
234
InceptionR
California
$1.26M
NSAM
235
North Star Asset Management
Wisconsin
$1.25M
Public Employees Retirement Association of Colorado
236
Public Employees Retirement Association of Colorado
Colorado
$1.17M
CM
237
Caption Management
Oklahoma
$1.17M
Brown Advisory
238
Brown Advisory
Maryland
$1.13M
LP
239
LMR Partners
United Kingdom
$1.13M
MGP
240
M&G plc
United Kingdom
$1.08M
IEFM
241
IQ EQ Fund Management
Ireland
$1.08M
BFG
242
Bleakley Financial Group
New Jersey
$1.07M
Canada Pension Plan Investment Board
243
Canada Pension Plan Investment Board
Ontario, Canada
$1.06M
DWM
244
Dynasty Wealth Management
Florida
$1.06M
PNC Financial Services Group
245
PNC Financial Services Group
Pennsylvania
$1.02M
WP
246
Westmount Partners
California
$973K
Truist Financial
247
Truist Financial
North Carolina
$965K
HCMT
248
Highland Capital Management (Tennessee)
Tennessee
$963K
AGWCA
249
Annis Gardner Whiting Capital Advisors
Florida
$961K
Allianz Asset Management
250
Allianz Asset Management
Germany
$946K