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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
Millennium Management
New York
$105M
3
PCH
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
$30.4M
5
WP
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
Citadel Advisors
Florida
$59.1M
3
O
OrbiMed
New York
$0
4
Invesco
Invesco
Georgia
$10.1M
5
CCM
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
IAIM
226
International Assets Investment Management
Florida
$324K – – –
AI
227
Atria Investments
North Carolina
$323K +$323K +8,186 New
PD
228
Point72 (DIFC)
United Arab Emirates
$320K -$1.31M -33,260 -80%
Principal Financial Group
229
Principal Financial Group
Iowa
$314K -$98.6K -2,496 -24%
M&T Bank
230
M&T Bank
New York
$303K +$303K +7,651 New
CB
231
Commerce Bank
Missouri
$301K +$13.1K +332 +5%
Fifth Third Bancorp
232
Fifth Third Bancorp
Ohio
$300K -$94.5K -2,391 -24%
Jones Financial Companies
233
Jones Financial Companies
Missouri
$286K -$260K -6,539 -48%
JG
234
Jain Global
New York
$284K -$55.3K -1,400 -16%
Mirae Asset Global ETFs Holdings
235
Mirae Asset Global ETFs Holdings
Hong Kong
$281K -$45.2K -1,135 -14%
SAM
236
Silvercrest Asset Management
New York
$279K +$6.56K +166 +2%
CA
237
Clearstead Advisors
Ohio
$277K – – –
Jacobs Levy Equity Management
238
Jacobs Levy Equity Management
New Jersey
$269K +$269K +6,813 New
ECM
239
Everence Capital Management
Indiana
$267K – – –
MAS
240
Meeder Advisory Services
Ohio
$263K +$263K +6,644 New
TCM
241
Teza Capital Management
Illinois
$261K -$144K -3,640 -36%
Mirae Asset Global Investments
242
Mirae Asset Global Investments
South Korea
$243K +$32.8K +829 +16%
AAM
243
Advisors Asset Management
Colorado
$237K -$1.94K -49 -0.8%
ProShare Advisors
244
ProShare Advisors
Maryland
$235K -$48.5K -1,228 -17%
FRA
245
Frank Rimerman Advisors
California
$228K +$228K +5,763 New
WPC
246
Wedmont Private Capital
Pennsylvania
$226K +$226K +5,282 New
Cambridge Investment Research Advisors
247
Cambridge Investment Research Advisors
Iowa
$224K -$44.2K -1,122 -16%
SC
248
Savant Capital
Illinois
$222K +$222K +5,607 New
BCI
249
Brinker Capital Investments
Pennsylvania
$221K +$221K +5,600 New
Franklin Resources
250
Franklin Resources
California
$220K +$220K +5,556 New
8 9
10
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