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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
IA
276
IFP Advisors
Florida
$48.8K -$13.3K -246 -21%
SPIA
277
Steward Partners Investment Advisory
New York
$48.2K +$5.18K +131 +12%
IUHSA
278
Itau Unibanco Holding S.A.
Brazil
$44.4K -$751 -19 -2%
EWA
279
EverSource Wealth Advisors
Alabama
$43.5K -$2.21K -56 -5%
LFG
280
Larson Financial Group
Missouri
$40.6K +$27K +684 +199%
SCM
281
Sterling Capital Management
North Carolina
$38K -$5.49K -139 -13%
GI
282
GAMMA Investing
California
$36.7K -$1.23K -31 -3%
SS
283
Sunbelt Securities
Texas
$35.4K – – –
A
284
AlphaQuest
New York
$33K +$7.9K +200 +31%
HNB
285
Huntington National Bank
Ohio
$31.4K -$11.8K -298 -27%
AF
286
Allworth Financial
California
$29.2K +$20.4K +517 +232%
AIC
287
Archer Investment Corporation
Indiana
$23.7K – – –
PFBT
288
Parkside Financial Bank & Trust
Missouri
$17.3K +$2.41K +61 +16%
FFA
289
Farther Finance Advisors
California
$17.1K -$1.54K -39 -8%
AF
290
Advisornet Financial
Minnesota
$16.9K +$16.8K +425 +14,167%
MCM
291
MAI Capital Management
Ohio
$16.8K +$6.56K +166 +64%
OWP
292
ORG Wealth Partners
Texas
$16K – – –
C
293
Covestor
United Kingdom
$12K +$275 +7 +2%
CAL
294
Capital Advisors Ltd
Ohio
$12K +$12K +295 New
EB
295
Eastern Bank
Massachusetts
$11.9K – – –
BIG
296
Brooklyn Investment Group
New York
$10.6K +$6.09K +154 +135%
UBP
297
Union Bancaire Privee
Switzerland
$10.5K – – –
GXJ
298
Global X Japan
Japan
$10.2K +$10.2K +259 New
MIM
299
MTM Investment Management
South Carolina
$10.2K +$10.2K +258 New
SS
300
SBI Securities
Japan
$10.2K -$119 -3 -1%
10 11
12
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