IONS icon

Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
FRA
301
Frank Rimerman Advisors
California
$434K
TE
302
Tema ETFs
New York
$426K
Robeco Institutional Asset Management
303
Robeco Institutional Asset Management
Netherlands
$425K
CCM
304
Coldstream Capital Management
Washington
$424K
CG
305
Cynosure Group
Utah
$422K
MFIM
306
Mesirow Financial Investment Management
Illinois
$410K
OIA
307
OneDigital Investment Advisors
Kansas
$405K
GIP
308
Granite Investment Partners
California
$401K
VF
309
Virtu Financial
New York
$401K
Vontobel Holding
310
Vontobel Holding
Switzerland
$393K
AI
311
Atria Investments
North Carolina
$392K
US Bancorp
312
US Bancorp
Minnesota
$379K
CIBC Asset Management
313
CIBC Asset Management
Ontario, Canada
$377K
CAPTRUST Financial Advisors
314
CAPTRUST Financial Advisors
North Carolina
$375K
MFT
315
Moisand Fitzgerald Tamayo
Florida
$375K
LIP
316
Lighthouse Investment Partners
Florida
$373K
FCM
317
Farallon Capital Management
California
$360K
NDSIB
318
North Dakota State Investment Board
North Dakota
$347K
VT
319
Vise Technologies
New York
$341K
TRCT
320
Tower Research Capital (TRC)
New York
$335K
CCA
321
Checchi Capital Advisers
California
$333K
Credit Agricole
322
Credit Agricole
France
$331K
KAS
323
Kestra Advisory Services
Texas
$328K
RS
324
R Squared
Hong Kong
$327K
PFS
325
Prospera Financial Services
Texas
$326K