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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Susquehanna International Group
251
Susquehanna International Group
Pennsylvania
$928K
SOAM
252
SBI Okasan Asset Management
Japan
$914K
AB
253
Amalgamated Bank
New York
$905K
OAM
254
Oppenheimer Asset Management
New York
$890K
STA
255
Summit Trail Advisors
New York
$867K
HKAM
256
Horizon Kinetics Asset Management
New York
$858K
VPIM
257
Vanguard Personalized Indexing Management
California
$857K
Cetera Investment Advisers
258
Cetera Investment Advisers
Illinois
$847K
PL
259
Plancorp LLC
Missouri
$843K
Northwestern Mutual Wealth Management
260
Northwestern Mutual Wealth Management
Wisconsin
$835K
CCM
261
Capstone Capital Management
$832K
Fifth Third Bancorp
262
Fifth Third Bancorp
Ohio
$827K
P
263
&Partners
Tennessee
$819K
SCM
264
Suvretta Capital Management
New York
$811K
VIA
265
Virtus Investment Advisers
Connecticut
$784K
FDCDDQ
266
Federation des caisses Desjardins du Quebec
Quebec, Canada
$751K
Thrivent Financial for Lutherans
267
Thrivent Financial for Lutherans
Minnesota
$748K
AssetMark Inc
268
AssetMark Inc
California
$719K
VA
269
Vident Advisory
Georgia
$713K
MIM
270
MetLife Investment Management
New Jersey
$693K
SLAM
271
Swiss Life Asset Management
$689K
Mirae Asset Global Investments
272
Mirae Asset Global Investments
South Korea
$678K
AIM
273
Aigen Investment Management
New York
$660K
Osaic Holdings
274
Osaic Holdings
Arizona
$654K
SC
275
Savant Capital
Illinois
$635K