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Ionis Pharmaceuticals

486 hedge funds and large institutions have $13.5B invested in Ionis Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 108 funds opening new positions, 166 increasing their positions, 141 reducing their positions, and 43 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
486
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$153M
Puts
$102M
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
CC
251
Cypress Capital
Tennessee
$791K
Thrivent Financial for Lutherans
252
Thrivent Financial for Lutherans
Minnesota
$788K
STA
253
Summit Trail Advisors
New York
$787K
P
254
&Partners
Tennessee
$769K
MIM
255
MetLife Investment Management
New Jersey
$765K
TSS
256
Two Sigma Securities
New York
$763K
IIM
257
INTECH Investment Management
Florida
$760K
KBC Group
258
KBC Group
Belgium
$716K
AIM
259
Aigen Investment Management
New York
$701K
AssetMark Inc
260
AssetMark Inc
California
$684K
NIM
261
NEOS Investment Management
Connecticut
$677K
TE
262
Tema ETFs
New York
$677K
Wealth Enhancement Advisory Services
263
Wealth Enhancement Advisory Services
Minnesota
$673K
VIA
264
Virtus Investment Advisers
Connecticut
$669K
SAM
265
Sectoral Asset Management
Quebec, Canada
$662K
DO
266
denkapparat Operations
Germany
$662K
URS
267
Utah Retirement Systems
Utah
$657K
MSRPS
268
Maryland State Retirement & Pension System
Maryland
$655K
Mirae Asset Global Investments
269
Mirae Asset Global Investments
South Korea
$654K
M&T Bank
270
M&T Bank
New York
$644K
CB
271
Commerce Bank
Missouri
$642K
Fifth Third Bancorp
272
Fifth Third Bancorp
Ohio
$624K
PAP
273
Persistent Asset Partners
Hong Kong
$618K
SWP
274
Stratos Wealth Partners
Ohio
$612K
GCM
275
Graham Capital Management
Connecticut
$601K