IONS icon

Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
CRWM
251
Castle Rock Wealth Management
California
$215K +$215K +5,122 New
CFO
252
Callan Family Office
Pennsylvania
$213K +$213K +5,400 New
Mitsubishi UFJ Asset Management
253
Mitsubishi UFJ Asset Management
Japan
$213K -$29.1K -737 -12%
HighTower Advisors
254
HighTower Advisors
Illinois
$212K +$212K +5,357 New
PWPS
255
Pinnacle Wealth Planning Services
Ohio
$209K +$209K +5,284 New
EF
256
Empowered Funds
Pennsylvania
$200K +$200K +5,067 New
MFT
257
Moisand Fitzgerald Tamayo
Florida
$198K – – –
WC
258
Wexford Capital
Florida
$188K +$188K +4,749 New
KBC Group
259
KBC Group
Belgium
$186K -$71.9K -1,816 -28%
US Bancorp
260
US Bancorp
Minnesota
$169K +$44.6K +1,128 +36%
GFM
261
GF Fund Management
China
$160K – – –
Osaic Holdings
262
Osaic Holdings
Arizona
$158K +$69.4K +1,854 +78%
SO
263
STRS Ohio
Ohio
$147K +$147K +3,714 New
CI Investments Inc
264
CI Investments Inc
Ontario, Canada
$95K -$4.95K -126 -5%
Carson Wealth (CWM LLC)
265
Carson Wealth (CWM LLC)
Nebraska
$92K -$4.64K -117 -5%
A
266
Allianz
Germany
$83K +$83K +2,100 New
S
267
SignatureFD
Georgia
$80.2K +$25.6K +648 +47%
AA
268
Ancora Advisors
Ohio
$79K – – –
PA
269
Parallel Advisors
California
$74K +$44.5K +1,127 +151%
HFM
270
Harvest Fund Management
China
$72K +$72K +1,829 New
Comerica Bank
271
Comerica Bank
Texas
$63.9K +$11.7K +297 +23%
TRCT
272
Tower Research Capital (TRC)
New York
$62.5K -$328K -8,292 -84%
TLCM
273
Twin Lakes Capital Management
California
$59.3K – – –
VCM
274
Versant Capital Management
Arizona
$57.9K +$53.9K +1,364 +1,350%
MCM
275
Manchester Capital Management
Vermont
$49.3K – – –
9 10
11
12 13