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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
P
201
&Partners
Tennessee
$465K +$29.8K +754 +7%
AB
202
Amalgamated Bank
New York
$455K +$37.6K +953 +9%
PNC Financial Services Group
203
PNC Financial Services Group
Pennsylvania
$451K +$16.8K +424 +4%
PL
204
Plancorp LLC
Missouri
$443K +$3.16K +80 +0.7%
FRM
205
Fox Run Management
Connecticut
$434K +$434K +10,988 New
SCM
206
Suvretta Capital Management
New York
$427K – – –
HA
207
Harbor Advisors
Florida
$415K – – –
Focus Partners Wealth
208
Focus Partners Wealth
Massachusetts
$397K +$8.85K +224 +2%
CC
209
Cypress Capital
Tennessee
$395K – – –
Westfield Capital Management
210
Westfield Capital Management
Massachusetts
$378K +$378K +9,561 New
PCP
211
Perbak Capital Partners
United Kingdom
$377K +$377K +9,538 New
SCM
212
Semanteon Capital Management
Massachusetts
$377K +$78.7K +1,993 +26%
FAM
213
Fred Alger Management
New York
$374K +$374K +9,464 New
Russell Investments Group
214
Russell Investments Group
United Kingdom
$366K +$139K +3,512 +61%
SAM
215
Sectoral Asset Management
Quebec, Canada
$364K -$9.29K -235 -2%
MIM
216
MetLife Investment Management
New Jersey
$362K +$672 +17 +0.2%
JF
217
Jump Financial
Illinois
$356K -$2.86M -72,303 -89%
Man Group
218
Man Group
United Kingdom
$354K -$42K -1,064 -11%
ETC
219
Exchange Traded Concepts
Oklahoma
$348K +$220K +5,558 +171%
Prudential Financial
220
Prudential Financial
New Jersey
$341K +$110K +2,991 +48%
Wealth Enhancement Advisory Services
221
Wealth Enhancement Advisory Services
Minnesota
$340K +$340K +7,915 New
FT
222
Fiduciary Trust
Massachusetts
$338K +$32.1K +813 +11%
URS
223
Utah Retirement Systems
Utah
$332K – – –
AIM
224
Aigen Investment Management
New York
$328K +$328K +8,298 New
MSRPS
225
Maryland State Retirement & Pension System
Maryland
$327K – – –
7 8
9
10 11