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Ionis Pharmaceuticals

490 hedge funds and large institutions have $13B invested in Ionis Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 177 increasing their positions, 155 reducing their positions, and 66 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding in top 10

Funds holding in top 10:

more funds holding

Funds holding:

0.75% less ownership

Funds ownership: 105.2%104.44% (-0.75%)

2% less call options, than puts

Call options by funds: $141M | Put options by funds: $144M

4% less capital invested

Capital invested by funds: $13.5B → $13B (-$517M)

Holders
490
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
14
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$141M
Puts
$144M
Net Calls
Net Calls Change

Top Buyers

1 +$255M
2 +$252M
3 +$212M
4
Millennium Management
Millennium Management
New York
+$75.6M
5
Artisan Partners
Artisan Partners
Wisconsin
+$69.2M

Top Sellers

1 -$235M
2 -$233M
3 -$94.1M
4
Nomura Holdings
Nomura Holdings
Japan
-$58M
5
TLP
Tri Locum Partners
New York
-$44.1M
Name Holding Trade Value Shares
Change
Change in
Stake
CGH
351
Crossmark Global Holdings
Texas
$240K
MML Investors Services
352
MML Investors Services
Massachusetts
$238K
GCP
353
GSA Capital Partners
United Kingdom
$238K
RMAM
354
Raab & Moskowitz Asset Management
New Jersey
$234K
CCIA
355
Campbell & Co Investment Adviser
Maryland
$233K
QCM
356
QRG Capital Management
Illinois
$232K
VWM
357
Venturi Wealth Management
Texas
$230K
LFG
358
Larson Financial Group
Missouri
$228K
ATC
359
Argent Trust Co
Tennessee
$227K
EC
360
EntryPoint Capital
New York
$222K
HWM
361
HB Wealth Management
Georgia
$220K
NG
362
Norden Group
Utah
$217K
CIM
363
Cambria Investment Management
California
$217K
BRWA
364
B. Riley Wealth Advisors
Florida
$214K
BAM
365
Blueshift Asset Management
New Jersey
$209K
AC
366
AlphaCore Capital
California
$207K
IWC
367
Integrated Wealth Concepts
Massachusetts
$205K
MF
368
Montis Financial
Massachusetts
$203K
Mitsubishi UFJ Asset Management
369
Mitsubishi UFJ Asset Management
Japan
$202K
NYLIM
370
New York Life Investment Management
New York
$202K
FAMI
371
Fideuram Asset Management (Ireland)
$182K
AA
372
Ancora Advisors
Ohio
$180K
S
373
SignatureFD
Georgia
$156K
Group One Trading
374
Group One Trading
Illinois
$142K
FFA
375
Farther Finance Advisors
California
$141K