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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
Millennium Management
New York
$105M
3
PCH
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
$30.4M
5
WP
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
Citadel Advisors
Florida
$59.1M
3
O
OrbiMed
New York
$0
4
Invesco
Invesco
Georgia
$10.1M
5
CCM
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
MWM
351
Mascoma Wealth Management
New Hampshire
$553 – – –
CPG
352
Cornerstone Planning Group
New Jersey
$517 +$517 +12 New
RIL
353
Rothschild Investment LLC
Illinois
$395 +$395 +10 New
PWM
354
Parkworth Wealth Management
California
$316 +$316 +8 New
TWD
355
True Wealth Design
Ohio
$277 -$237 -6 -46%
Kayne Anderson Rudnick Investment Management
356
Kayne Anderson Rudnick Investment Management
California
$277 +$277 +7 New
IAS
357
IMA Advisory Services
Colorado
$198 +$198 +5 New
WCM
358
WealthTrak Capital Management
Virginia
$198 +$198 +5 New
CIBC Private Wealth Group
359
CIBC Private Wealth Group
Georgia
$79 -$1.11K -28 -93%
TC
360
Truvestments Capital
Florida
$30 -$1.17K -39 -98%
O
361
OrbiMed
New York
– -$76.6M -2,540,136 Closed
CCM
362
Camber Capital Management
Massachusetts
– -$21.9M -725,000 Closed
BBA
363
Baker Bros. Advisors
New York
– -$10.8M -357,915 Closed
SFI
364
Susquehanna Fundamental Investments
Pennsylvania
– -$4.79M -158,609 Closed
Susquehanna International Group
365
Susquehanna International Group
Pennsylvania
– -$2.17M -71,811 Closed
SFM
366
Sphera Funds Management
Israel
– -$1.93M -63,821 Closed
APM
367
Avidity Partners Management
Texas
– -$1.81M -60,000 Closed
Jane Street
368
Jane Street
New York
– -$1.63M -54,117 Closed
RAM
369
Readystate Asset Management
Illinois
– -$1.4M -46,394 Closed
AI
370
Allostery Investments
Connecticut
– -$1.06M -35,000 Closed
PAG
371
Private Advisor Group
New Jersey
– -$1.04M -34,531 Closed
LIP
372
Liontrust Investment Partners
United Kingdom
– -$917K -30,390 Closed
AC
373
AXQ Capital
New Jersey
– -$908K -30,104 Closed
ECM
374
ExodusPoint Capital Management
New York
– -$792K -26,261 Closed
HF
375
HRT Financial
New York
– -$779K -25,824 Closed
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15
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