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Ionis Pharmaceuticals
IONS

Overview Fund Activity

360 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 108 reducing their positions, and 58 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
360
Holders Change
+21
Holders Change %
+6.19%
% of All Funds
4.83%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
108
Closed
58
Calls
$65.2M
Puts
$30M
Net Calls
+$35.2M
Net Calls Change
+$29.2M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
Millennium Management
New York
$105M
3
PCH
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
$30.4M
5
WP
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
Citadel Advisors
Florida
$59.1M
3
O
OrbiMed
New York
$0
4
Invesco
Invesco
Georgia
$10.1M
5
CCM
Camber Capital Management
Massachusetts
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
BCM
376
BlueCrest Capital Management
Jersey
– -$748K -24,800 Closed
CHP
377
Castle Hook Partners
New York
– -$722K -23,940 Closed
TI
378
Tidal Investments
Wisconsin
– -$659K -21,833 Closed
BC
379
Bridgefront Capital
Texas
– -$619K -20,528 Closed
SG Americas Securities
380
SG Americas Securities
New York
– -$605K -20,050 Closed
NB
381
NBT Bank
New York
– -$514K -17,050 Closed
VRS
382
Virginia Retirement Systems
Virginia
– -$498K -16,522 Closed
TC
383
TwinBeech Capital
New York
– -$481K -15,938 Closed
PHK
384
Point72 Hong Kong
Hong Kong
– -$388K -12,862 Closed
XT
385
XTX Topco
Cayman Islands
– -$374K -12,404 Closed
IIM
386
INTECH Investment Management
Florida
– -$368K -12,207 Closed
SP
387
SIH Partners
Delaware
– -$362K -11,999 Closed
FC
388
FORA Capital
Florida
– -$349K -11,570 Closed
Twin Tree Management
389
Twin Tree Management
Texas
– -$343K -11,385 Closed
CM
390
Capula Management
Cayman Islands
– -$313K -10,382 Closed
Walleye Trading
391
Walleye Trading
New York
– -$282K -9,361 Closed
Amundi
392
Amundi
France
– -$110K -3,873 Closed
QL
393
Quarry LP
New York
– -$90.5K -3,000 Closed
CF
394
Corebridge Financial
Texas
– -$80.2K -2,657 Closed
SIM
395
Sandia Investment Management
Massachusetts
– -$75.4K -2,500 Closed
CCM
396
Coldstream Capital Management
Washington
– -$70.8K -2,345 Closed
PAS
397
Point72 Asia (Singapore)
Singapore
– -$62.8K -2,082 Closed
RTC
398
Riverview Trust Company
Washington
– -$14.4K -476 Closed
MG
399
Mather Group
Illinois
– -$12.4K -410 Closed
QCG
400
Quadrant Capital Group
Ohio
– -$11.5K -381 Closed
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