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Ionis Pharmaceuticals
IONS

Overview Fund Activity

358 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 107 reducing their positions, and 57 closing their positions.

Holders
358
Holders Change
+19
Holders Change %
+5.6%
% of All Funds
4.81%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
107
Closed
57
Calls
$48.1M
Puts
$26.1M
Net Calls
+$22M
Net Calls Change
+$16M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Market Value Shares Shares
Change 		Shares
Change %
Neuberger Berman Group
101
Neuberger Berman Group
New York
$4.53M 114,623 +12,150 +12%
HSBC Holdings
102
HSBC Holdings
United Kingdom
$4.29M 108,294 +33,461 +45%
SEI Investments
103
SEI Investments
Pennsylvania
$3.89M 98,348 +26,790 +37%
SCM
104
Superstring Capital Management
New York
$3.88M 98,267 +98,267 New
State of Wisconsin Investment Board
105
State of Wisconsin Investment Board
Wisconsin
$3.82M 96,694 -11,622 -11%
DekaBank Deutsche Girozentrale
106
DekaBank Deutsche Girozentrale
Germany
$3.72M 93,807 – –
SPS
107
Susquehanna Portfolio Strategies
Pennsylvania
$3.67M 92,900 +92,900 New
DA
108
DCF Advisers
Connecticut
$3.63M 91,750 -3,250 -3%
NWM
109
Nicola Wealth Management
British Columbia, Canada
$3.44M 87,000 – –
New York State Common Retirement Fund
110
New York State Common Retirement Fund
New York
$3.44M 86,972 +8,711 +11%
Deutsche Bank
111
Deutsche Bank
Germany
$3.37M 85,278 +468 +0.6%
Manulife (Manufacturers Life Insurance)
112
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$3.29M 83,386 -54 -0.1%
MG
113
Marex Group
$3.29M 83,361 +83,361 New
UOC
114
UBS O'Connor
Illinois
$3.21M 81,251 -9,528 -10%
WorldQuant Millennium Advisors
115
WorldQuant Millennium Advisors
New York
$2.94M 74,438 +74,438 New
VanEck Associates
116
VanEck Associates
New York
$2.91M 73,617 +71,460 +3,313%
Treasurer of the State of North Carolina
117
Treasurer of the State of North Carolina
North Carolina
$2.87M 72,587 +994 +1%
Walleye Capital
118
Walleye Capital
New York
$2.63M 66,482 -28,508 -30%
DC
119
Davenport & Co
Virginia
$2.56M 64,843 +8,450 +15%
VOYA Investment Management
120
VOYA Investment Management
Georgia
$2.55M 64,517 +750 +1%
Janus Henderson Group
121
Janus Henderson Group
United Kingdom
$2.52M 63,877 – –
Lazard Asset Management
122
Lazard Asset Management
New York
$2.4M 60,749 -9 -0%
PFSRSONJ
123
Police & Firemen's Retirement System of New Jersey
New Jersey
$2.36M 59,723 +2,174 +4%
Skandinaviska Enskilda Banken (SEB)
124
Skandinaviska Enskilda Banken (SEB)
Sweden
$2.36M 59,626 – –
State of New Jersey Common Pension Fund D
125
State of New Jersey Common Pension Fund D
New Jersey
$2.33M 58,918 -1,744 -3%
3 4
5
6 7