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Ionis Pharmaceuticals
IONS

Overview Fund Activity

358 hedge funds and large institutions have $6.67B invested in Ionis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 81 funds opening new positions, 121 increasing their positions, 107 reducing their positions, and 57 closing their positions.

Holders
358
Holders Change
+19
Holders Change %
+5.6%
% of All Funds
4.81%
Holding in Top 10
12
Holding in Top 10 Change
+6
Holding in Top 10 Change %
+100%
% of All Funds
0.16%
New
81
Increased
121
Reduced
107
Closed
57
Calls
$48.1M
Puts
$26.1M
Net Calls
+$22M
Net Calls Change
+$16M

Top Buyers

1
Adage Capital Partners
1
Adage Capital Partners
Massachusetts
$150M
2
Millennium Management
2
Millennium Management
New York
$105M
3
PCH
3
Polar Capital Holdings
United Kingdom
$39.5M
4
Balyasny Asset Management
4
Balyasny Asset Management
Illinois
$30.4M
5
WP
5
Woodline Partners
California
$29M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$251M
2
Citadel Advisors
2
Citadel Advisors
Florida
$59.1M
3
O
3
OrbiMed
New York
$0
4
Invesco
4
Invesco
Georgia
$10.1M
5
CCM
5
Camber Capital Management
Massachusetts
$0
Name Market Value Shares Shares
Change 		Shares
Change %
EDRH
76
Edmond de Rothschild Holding
Switzerland
$7.81M 197,600 +73,400 +59%
Stifel Financial
77
Stifel Financial
Missouri
$7.76M 196,357 -4,585 -2%
TAM
78
Tocqueville Asset Management
New York
$7.4M 187,345 -50 -0%
SA
79
Sicart Associates
New York
$7.32M 185,296 -350 -0.2%
RPAM
80
Rhenman & Partners Asset Management
Sweden
$7.19M 182,000 +101,000 +125%
RhumbLine Advisers
81
RhumbLine Advisers
Massachusetts
$7.17M 181,599 -6,617 -4%
BNP Paribas Financial Markets
82
BNP Paribas Financial Markets
France
$7.02M 177,762 -130,531 -42%
SIMG
83
Sonora Investment Management Group
Arizona
$6.45M 163,172 +9,025 +6%
Alyeska Investment Group
84
Alyeska Investment Group
Illinois
$6.28M 159,008 +159,008 New
ACM
85
Aquatic Capital Management
Illinois
$6.25M 158,086 +1,929 +1%
State Board of Administration of Florida Retirement System
86
State Board of Administration of Florida Retirement System
Florida
$6.08M 153,895 +1,580 +1%
BBA
87
BLB&B Advisors
Pennsylvania
$5.99M 151,550 -650 -0.4%
TCM
88
Tang Capital Management
California
$5.93M 150,000 – –
Universal-Beteiligungs- und Servicegesellschaft
89
Universal-Beteiligungs- und Servicegesellschaft
Germany
$5.92M 149,839 +5,969 +4%
ACM
90
ADAR1 Capital Management
Texas
$5.87M 148,461 +148,461 New
JGC
91
J. Goldman & Co
New York
$5.83M 147,682 -160,088 -52%
California State Teachers Retirement System (CalSTRS)
92
California State Teachers Retirement System (CalSTRS)
California
$5.73M 145,104 +12,866 +10%
Rafferty Asset Management
93
Rafferty Asset Management
New York
$5.72M 144,770 -31,478 -18%
Sumitomo Mitsui Trust Group
94
Sumitomo Mitsui Trust Group
Japan
$5.52M 139,739 -2,694 -2%
NAMA
95
Nikko Asset Management Americas
New York
$5.52M 139,739 -2,694 -2%
Squarepoint
96
Squarepoint
New York
$5.31M 134,395 -170,978 -56%
KCM
97
Kennedy Capital Management
Missouri
$5.22M 132,045 -18,379 -12%
TI
98
Trexquant Investment
Connecticut
$5.09M 128,869 +128,869 New
EAM
99
Exome Asset Management
New York
$4.79M 121,116 -14,500 -11%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
100
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$4.58M 116,000 +116,000 New
2 3
4
5 6