|
1
|
|
$271M
|
–
|
–
|
–
|
|
|
2
|
RA Capital Management
Boston,
Massachusetts
|
$160M
|
–
|
–
|
–
|
|
|
3
|
Novo Holdings A/S
Hellerup,
Denmark
|
$114M
|
+$111M
|
+6,344,430
|
New
|
|
|
4
|
|
$108M
|
+$14.8M
|
+848,705
|
+16%
|
|
|
5
|
Baker Bros. Advisors
New York
|
$105M
|
–
|
–
|
–
|
|
|
6
|
Fidelity Investments
Boston,
Massachusetts
|
$86.1M
|
-$27.6M
|
-1,585,161
|
-25%
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
$81.2M
|
+$8.56M
|
+490,733
|
+12%
|
|
|
8
|
Frazier Life Sciences Management
Palo Alto,
California
|
$67.2M
|
+$7.46M
|
+427,500
|
+13%
|
|
|
9
|
Cormorant Asset Management
Boston,
Massachusetts
|
$54.1M
|
–
|
–
|
–
|
|
|
10
|
Deerfield Management
New York
|
$51.8M
|
–
|
–
|
–
|
|
|
11
|
Janus Henderson Group
London,
|
$46.9M
|
+$14M
|
+801,987
|
+44%
|
|
|
12
|
Citadel Advisors
Miami,
Florida
|
$42.3M
|
-$6.46M
|
-370,117
|
-14%
|
|
|
13
|
Paradigm Biocapital Advisors
New York
|
$41.9M
|
-$2.11M
|
-120,924
|
-5%
|
|
|
14
|
TCG Crossover Management
Palo Alto,
California
|
$40.9M
|
–
|
–
|
–
|
|
|
15
|
Perceptive Advisors
New York
|
$33.4M
|
-$8.08M
|
-463,229
|
-20%
|
|
|
16
|
|
$32.7M
|
–
|
–
|
–
|
|
|
17
|
Geode Capital Management
Boston,
Massachusetts
|
$30.1M
|
+$5.28M
|
+302,756
|
+22%
|
|
|
18
|
State Street
Boston,
Massachusetts
|
$30M
|
+$7.91M
|
+453,619
|
+37%
|
|
|
19
|
|
$29.2M
|
-$2.18M
|
-125,103
|
-7%
|
|
|
20
|
New Leaf Venture Partners
New York
|
$28M
|
–
|
–
|
–
|
|
|
21
|
Viking Global Investors
Stamford,
Connecticut
|
$26.7M
|
-$32.4M
|
-1,858,000
|
-56%
|
|
|
22
|
Bellevue Group
Kuesnacht,
Switzerland
|
$25.7M
|
+$24.9M
|
+1,428,929
|
New
|
|
|
23
|
Driehaus Capital Management
Chicago,
Illinois
|
$22.7M
|
-$130K
|
-7,427
|
-0.6%
|
|
|
24
|
EcoR1 Capital
San Francisco,
California
|
$22.5M
|
–
|
–
|
–
|
|
|
25
|
Millennium Management
New York
|
$20.6M
|
+$10.7M
|
+613,251
|
+115%
|
|
