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Sio Capital Management Portfolio holdings

AUM $697M
1-Year Est. Return 79.73%
This Fund
S&P 500
This Quarter Est. Return
+50.35%
1 Year Est. Return
+79.73%
3 Year Est. Return
+576.62%
5 Year Est. Return
+422.76%
10 Year Est. Return
+2,506.65%
AUM
$395M
AUM Growth
+$133M
Cap. Flow
+$73.6M
Cap. Flow %
18.64%
Top 10 Hldgs %
59.5%
Holding
66
New
14
Increased
6
Reduced
13
Closed
15

Top Buys

Rank Stock Value
1
CELC icon
Celcuity
CELC
+$31.5M
2
ALKS icon
Alkermes
ALKS
+$19M
3
SNY icon
Sanofi
SNY
+$18.1M
4
KVUE icon
Kenvue
KVUE
+$17.2M
5
HSIC icon
Henry Schein
HSIC
+$15.2M

Top Sells

Rank Stock Value
1
GMED icon
Globus Medical
GMED
+$14.5M
2
NBIX icon
Neurocrine Biosciences
NBIX
+$12.7M
3
DRUG
Bright Minds Biosciences
DRUG
+$12.5M
4
ANNX icon
Annexon
ANNX
+$9.83M
5
SEPN
Septerna Inc
SEPN
+$5.19M

Sector Composition

Rank Sector Weight
1 Healthcare 83.63%
2 Industrials 12.89%
3 Consumer Staples 3.47%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PRQR icon
26
ProQR Therapeutics
PRQR
$258M
$4.42M 1.12%
2,075,139
– –
SI
27
Shoulder Innovations Inc
SI
$471M
$4.39M 1.11%
+350,000
New +$4.89M
PMVP icon
28
PMV Pharmaceuticals
PMVP
$62.4M
$3.69M 0.93%
2,636,548
-1,098,848
-29% -$1.52M
SEPN
29
Septerna Inc
SEPN
$1.76B
$3.56M 0.9%
189,199
-395,236
-68% -$5.19M
IDYA icon
30
IDEAYA Biosciences
IDYA
$3.48B
$3.38M 0.86%
124,230
– –
ALGS icon
31
Aligos Therapeutics
ALGS
$29.4M
$3.29M 0.83%
335,937
– –
ERAS icon
32
Erasca
ERAS
$6.38B
$2.99M 0.76%
1,369,748
– –
VIR icon
33
Vir Biotechnology
VIR
$1.55B
$2.73M 0.69%
478,343
– –
SVRA icon
34
Savara
SVRA
$1.11B
$2.59M 0.66%
726,851
– –
VTYX
35
DELISTED
Ventyx Biosciences
VTYX
$2.58M 0.65%
829,178
-478,786
-37% -$1.27M
NMTC icon
36
NeuroOne Medical Technologies
NMTC
$14.7M
$2.1M 0.53%
393,439
-193,838
-33% -$949K
OVID icon
37
Ovid Therapeutics
OVID
$474M
$1.86M 0.47%
1,427,495
-804,505
-36% -$697K
BBOT
38
BridgeBio Oncology
BBOT
$711M
$1.51M 0.38%
+130,628
New +$1.36M
CNTX icon
39
Context Therapeutics
CNTX
$57.1M
$1.3M 0.33%
1,341,636
– –
SENS icon
40
Senseonics Holdings Inc
SENS
$282M
$1.01M 0.26%
115,787
-126,828
-52% -$1.22M
TELA icon
41
TELA Bio
TELA
$40.6M
$948K 0.24%
636,300
– –
AVTX icon
42
Avalo Therapeutics
AVTX
$980M
$917K 0.23%
72,173
– –
FHTX icon
43
Foghorn Therapeutics
FHTX
$285M
$601K 0.15%
122,889
– –
MODD icon
44
Modular Medical
MODD
$11.7M
$550K 0.14%
26,194
– –
NYXH
45
Nyxoah
NYXH
$145M
$234K 0.06%
50,839
– –
BOLD
46
Boundless Bio
BOLD
$60.9M
$201K 0.05%
163,679
– –
APRE icon
47
Aprea Therapeutics
APRE
$7.42M
$166K 0.04%
112,223
-167,146
-60% -$275K
TERN
48
DELISTED
Terns Pharmaceuticals
TERN
$75.9K 0.02%
10,100
– –
NXTC icon
49
NextCure
NXTC
$23.5M
$64.1K 0.02%
10,940
-2
-0% -$10
RCKTW icon
50
Rocket Pharmaceuticals Warrant
RCKTW
$192K
$14.4K ﹤0.01%
400,000
– –
1
2
3

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Sio Capital Management's Q3 2025 Portfolio in Review

As of Q3 2025, Sio Capital Management held 66 positions worth $395M, up 51% from $262M the previous quarter. Its ten largest holdings account for 60% of the portfolio.

Sio Capital Management deployed $73.6M of net new capital in Q3 2025, opening 14 new positions and adding to 6 existing holdings. Its largest new stake was Celcuity: 786,526 shares worth $38.9M.

By sector, the portfolio is most concentrated in Healthcare at 84% of assets, up from 80% a quarter earlier, followed by Industrials and Consumer Staples.

On the sell side, the largest reduction was Bright Minds Biosciences, an estimated $12.5M trimmed.

  • Sio Capital Management's largest Q3 2025 buy was Celcuity: 786,526 shares worth $38.9M.
  • Sio Capital Management added most to Sanofi in Q3 2025, an estimated $18.1M increase.
  • Sio Capital Management's biggest Q3 2025 reduction was Bright Minds Biosciences, cutting an estimated $12.5M.
  • Sio Capital Management fully exited Globus Medical in Q3 2025, selling an estimated $14.5M.
  • Sio Capital Management's ten largest holdings make up 60% of its $395M portfolio in Q3 2025.
  • Sio Capital Management opened 14 new positions and closed 15 in Q3 2025.
  • Sio Capital Management's portfolio value rose 51% quarter-over-quarter to $395M.

Based on Sio Capital Management's 13F filing for Q3 2025, filed 13 Nov 2025.