UPB

Upstream Bio, Inc. Common Stock

82 hedge funds and large institutions have $531M invested in Upstream Bio, Inc. Common Stock in 2025 Q2 according to their latest regulatory filings, with 14 funds opening new positions, 41 increasing their positions, 13 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
82
Holders Change
+4
Holders Change %
+5.13%
% of All Funds
1.1%
Holding in Top 10
4
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.05%
New
14
Increased
41
Reduced
13
Closed
10
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Shares
Change %
Nisa Investment Advisors
76
Nisa Investment Advisors
Missouri
$1.05K -$439 -40 -29%
AF
77
Allworth Financial
California
$725 -$1.31K -119 -64%
S
78
SignatureFD
Georgia
$538 -$450 -41 -46%
TWD
79
True Wealth Design
Ohio
$341 +$165 +15 +94%
Osaic Holdings
80
Osaic Holdings
Arizona
$257 +$257 +42 New
PA
81
Parallel Advisors
California
$22 +$22 +2 New
IA
82
IFP Advisors
Florida
$11 +$11 +1 New
Millennium Management
83
Millennium Management
New York
-$378K -61,796 Closed
EC
84
EcoR1 Capital
California
-$367K -60,000 Closed
Goldman Sachs
85
Goldman Sachs
New York
-$202K -32,955 Closed
Two Sigma Investments
86
Two Sigma Investments
New York
-$133K -21,789 Closed
ACM
87
ADAR1 Capital Management
Texas
-$91.8K -15,000 Closed
XT
88
XTX Topco
Cayman Islands
-$77.9K -12,731 Closed
Walleye Capital
89
Walleye Capital
New York
-$61.2K -10,000 Closed
CF
90
Corebridge Financial
Texas
-$52.2K -8,533 Closed
PWA
91
Physician Wealth Advisors
Utah
-$423 -69 Closed
PS
92
Principal Securities
Iowa
-$197 -12 Closed