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Praxis Precision Medicines
PRAX

150 hedge funds and large institutions have $889M invested in Praxis Precision Medicines in 2025 Q1 according to their latest regulatory filings, with 33 funds opening new positions, 47 increasing their positions, 53 reducing their positions, and 45 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

0.2% less ownership

Funds ownership: 116.53% → 116.33% (-0.2%)

7% less funds holding

Funds holding: 162 → 150 (-12)

11% less repeat investments, than reductions

Existing positions increased: 47 | Existing positions reduced: 53

22% less call options, than puts

Call options by funds: $17.8M | Put options by funds: $22.8M

27% less first-time investments, than exits

New positions opened: 33 | Existing positions closed: 45

47% less capital invested

Capital invested by funds: $1.67B → $889M (-$782M)

Holders
150
Holders Change
-12
Holders Change %
-7.41%
% of All Funds
2.01%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
33
Increased
47
Reduced
53
Closed
45
Calls
$17.8M
Puts
$22.8M
Net Calls
-$5.03M
Net Calls Change
-$50.5M

Top Buyers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
+$71.1M
2
SCM
Soleus Capital Management
Connecticut
+$56M
3
DM
Deerfield Management
New York
+$38.7M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$36M
5
Bank of America
Bank of America
North Carolina
+$28.4M

Top Sellers

1
RCM
RA Capital Management
Massachusetts
-$58.6M
2
KCM
Kingdon Capital Management
New York
-$23.3M
3
PA
Perceptive Advisors
New York
-$21.8M
4
N
Nuveen
North Carolina
-$18.2M
5
Verition Fund Management
Verition Fund Management
Connecticut
-$16.5M
Name Holding Trade Value Shares
Change 		Change in
Stake
Goldman Sachs
26
Goldman Sachs
New York
$6.71M -$6.38M -102,131 -37%
WP
27
Woodline Partners
California
$6.65M +$10.4M +165,779 +1,666%
5VM
28
5AM Venture Management
California
$6.44M – – –
SCM
29
Silverarc Capital Management
Massachusetts
$6.29M +$5.84M +93,558 +129%
Northern Trust
30
Northern Trust
Illinois
$6.26M -$150K -2,407 -1%
PHS
31
PFM Health Sciences
California
$6.09M +$2.58M +41,357 +35%
SI
32
Sofinnova Investments
California
$5.97M +$9.84M +157,640 New
Alyeska Investment Group
33
Alyeska Investment Group
Illinois
$5.68M -$4.8M -76,788 -34%
IC
34
Ikarian Capital
Texas
$5.51M +$9.09M +145,502 New
Charles Schwab
35
Charles Schwab
California
$5.34M -$113K -1,812 -1%
SFM
36
Sphera Funds Management
Israel
$5.33M +$3.06M +49,077 +54%
Walleye Capital
37
Walleye Capital
New York
$4.99M +$2.63M +42,143 +47%
SCM
38
Sio Capital Management
New York
$4.26M +$7.03M +112,500 New
ABG
39
Ally Bridge Group
New York
$3.62M +$3.16M +50,600 +112%
Aberdeen Group
40
Aberdeen Group
United Kingdom
$3.33M +$5.18M +82,904 +1,658%
ACP
41
Acuta Capital Partners
California
$3.3M +$1.23M +19,641 +29%
UBS AM
42
UBS AM
Illinois
$3.3M +$4.28M +68,466 +368%
Norges Bank
43
Norges Bank
Norway
$3.19M -$2.17M -34,700 -29%
TLP
44
Tri Locum Partners
New York
$3.17M +$2.9M +46,390 +124%
Pictet Asset Management
45
Pictet Asset Management
Switzerland
$2.98M +$2.07M +33,161 +73%
FTM
46
First Turn Management
California
$2.72M +$1.64M +26,239 +58%
Millennium Management
47
Millennium Management
New York
$2.62M -$5.1M -81,711 -54%
7IH
48
72 Investment Holdings
Connecticut
$2.5M – – –
KCM
49
Kennedy Capital Management
Missouri
$2.47M +$4.08M +65,265 New
CS
50
Candriam SCA
Luxembourg
$2.41M -$3.39M -54,299 -46%
1
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PRAX Hedge Fund Activity: Q1 2025 in Review

150 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Praxis Precision Medicines (PRAX) for Q1 2025, worth a combined $889M — down 47% from $1.67B a quarter earlier.

Sellers outnumbered buyers: 45 funds closed out of PRAX and 33 opened new positions — a net loss of 12 holders — while 53 trimmed existing stakes and 47 added.

The largest buyer was Adage Capital Partners, adding an estimated $71.1M. The largest seller was RA Capital Management, exiting entirely with an estimated $58.6M sold.

  • 150 institutional investors held Praxis Precision Medicines (PRAX) as of Q1 2025, down from 162 in Q4 2024.
  • Funds reported $889M of Praxis Precision Medicines stock for Q1 2025, down 47% quarter-over-quarter.
  • 33 funds opened new Praxis Precision Medicines positions in Q1 2025 and 45 closed out, a net change of -12 holders.
  • The largest Praxis Precision Medicines buyer in Q1 2025 was Adage Capital Partners, an estimated $71.1M added.
  • The largest Praxis Precision Medicines seller in Q1 2025 was RA Capital Management, an estimated $58.6M sold.

Based on aggregated 13F filings for Q1 2025.