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Praxis Precision Medicines

289 hedge funds and large institutions have $10.2B invested in Praxis Precision Medicines in 2026 Q1 according to their latest regulatory filings, with 79 funds opening new positions, 121 increasing their positions, 67 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed

139% more first-time investments, than exits

New positions opened: 79 | Existing positions closed: 33

81% more repeat investments, than reductions

Existing positions increased: 121 | Existing positions reduced: 67

18% more capital invested

Capital invested by funds: $8.69B → $10.2B (+$1.55B)

16% more funds holding

Funds holding: 250289 (+39)

3.69% less ownership

Funds ownership: 117.84%114.15% (-3.7%)

4% less funds holding in top 10

Funds holding in top 10: 2423 (-1)

71% less call options, than puts

Call options by funds: $53.8M | Put options by funds: $187M

Holders
289
Holders Change
+39
Holders Change %
+15.6%
% of All Funds
3.56%
Holding in Top 10
23
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-4.17%
% of All Funds
0.28%
New
79
Increased
121
Reduced
67
Closed
33
Calls
$53.8M
Puts
$187M
Net Calls
-$133M
Net Calls Change
-$115M
Name Holding Trade Value Shares
Change
Change in
Stake
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$1.11B +$67.7M +218,777 +7%
OAG
2
Orbis Allan Gray
Bermuda
$797M +$377M +1,217,318 +97%
BlackRock
3
BlackRock
New York
$749M +$76.2M +246,429 +12%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$696M +$248M +802,268 +59%
PA
5
Perceptive Advisors
New York
$656M +$12.4M +40,000 +2%
BBA
6
Baker Bros. Advisors
New York
$565M +$194M +626,710 +56%
VCM
7
Vanguard Capital Management
Pennsylvania
$394M +$378M +1,221,944 New
DM
8
Deerfield Management
New York
$310M +$18.6M +60,000 +7%
DCM
9
Driehaus Capital Management
Illinois
$306M +$5M +16,164 +2%
CAM
10
Cormorant Asset Management
Massachusetts
$285M -$20M -64,500 -7%
State Street
11
State Street
Massachusetts
$285M +$626K +2,023 +0.2%
Morgan Stanley
12
Morgan Stanley
New York
$269M -$17.4M -56,398 -6%
Adage Capital Partners
13
Adage Capital Partners
Massachusetts
$263M -$46.3M -149,574 -15%
VPM
14
Vanguard Portfolio Management
Pennsylvania
$244M +$234M +756,748 New
Goldman Sachs
15
Goldman Sachs
New York
$229M -$1.69M -5,450 -0.8%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$210M +$27.4M +88,525 +16%
T. Rowe Price Associates
17
T. Rowe Price Associates
Maryland
$203M -$48M -155,135 -20%
Bank of America
18
Bank of America
North Carolina
$172M +$3.66M +11,841 +2%
RCM
19
RA Capital Management
Massachusetts
$120M
HRCM
20
Hood River Capital Management
Florida
$116M +$21.4M +69,151 +24%
VC
21
Vivo Capital
California
$109M +$3.09M +10,000 +3%
SCM
22
Soleus Capital Management
Connecticut
$106M -$10M -32,449 -9%
LGM
23
Logos Global Management
California
$91.8M -$27.8M -90,000 -24%
Pictet Asset Management
24
Pictet Asset Management
Switzerland
$91.4M +$14.2M +46,056 +19%
Franklin Resources
25
Franklin Resources
California
$89M -$24.7M -79,951 -22%