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Praxis Precision Medicines
PRAX

162 hedge funds and large institutions have $1.67B invested in Praxis Precision Medicines in 2024 Q4 according to their latest regulatory filings, with 38 funds opening new positions, 56 increasing their positions, 52 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

280% more first-time investments, than exits

New positions opened: 38 | Existing positions closed: 10

155% more call options, than puts

Call options by funds: $74.7M | Put options by funds: $29.3M

53% more capital invested

Capital invested by funds: $1.09B → $1.67B (+$580M)

40% more funds holding in top 10

Funds holding in top 10: 5 → 7 (+2)

21% more funds holding

Funds holding: 134 → 162 (+28)

10.29% more ownership

Funds ownership: 106.24% → 116.53% (+10%)

8% more repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 52

Holders
162
Holders Change
+28
Holders Change %
+20.9%
% of All Funds
2.13%
Holding in Top 10
7
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+40%
% of All Funds
0.09%
New
38
Increased
56
Reduced
52
Closed
10
Calls
$74.7M
Puts
$29.3M
Net Calls
+$45.5M
Net Calls Change
+$41.4M

Top Buyers

1
Morgan Stanley
Morgan Stanley
New York
+$78.4M
2
CAM
Cormorant Asset Management
Massachusetts
+$59.6M
3
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$39.7M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$29.4M
5
VA
VR Adviser
New York
+$20.5M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$37M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$18M
3
5VM
5AM Venture Management
California
-$12.3M
4
Wellington Management Group
Wellington Management Group
Massachusetts
-$11.3M
5
Marshall Wace
Marshall Wace
United Kingdom
-$8.09M
Name Holding Trade Value Shares
Change 		Change in
Stake
CAM
1
Cormorant Asset Management
Massachusetts
$130M +$59.6M +823,219 +95%
BlackRock
2
BlackRock
New York
$113M +$11.6M +160,010 +12%
PA
3
Perceptive Advisors
New York
$102M +$12M +165,700 +14%
T. Rowe Price Associates
4
T. Rowe Price Associates
Maryland
$93M +$6.4M +88,442 +8%
Morgan Stanley
5
Morgan Stanley
New York
$89.5M +$78.4M +1,083,026 +1,345%
Vanguard Group
6
Vanguard Group
Pennsylvania
$81.9M +$1.78M +24,645 +2%
Capital Research Global Investors
7
Capital Research Global Investors
California
$76.5M -$255K -3,525 -0.4%
VA
8
VR Adviser
New York
$76.2M +$20.5M +283,854 +40%
Janus Henderson Group
9
Janus Henderson Group
United Kingdom
$71.6M +$29.4M +405,957 +78%
State Street
10
State Street
Massachusetts
$59.2M -$1.52M -20,969 -3%
RCM
11
RA Capital Management
Massachusetts
$58.6M – – –
Adage Capital Partners
12
Adage Capital Partners
Massachusetts
$46.6M -$18M -249,073 -29%
Assenagon Asset Management
13
Assenagon Asset Management
Luxembourg
$43M +$39.7M +548,986 +5,438%
Point72 Asset Management
14
Point72 Asset Management
Connecticut
$40.1M -$37M -511,971 -50%
Verition Fund Management
15
Verition Fund Management
Connecticut
$35.7M -$6.85M -94,643 -17%
Geode Capital Management
16
Geode Capital Management
Massachusetts
$31.3M +$570K +7,873 +2%
Franklin Resources
17
Franklin Resources
California
$30M -$4.01M -55,398 -12%
CIBC Asset Management
18
CIBC Asset Management
Ontario, Canada
$28.2M +$8.52M +117,817 +47%
BBA
19
Baker Bros. Advisors
New York
$25.5M +$610K +8,428 +3%
N
20
Nuveen
North Carolina
$23.6M +$151K +2,084 +0.7%
KCM
21
Kingdon Capital Management
New York
$23.3M -$4.7M -65,000 -18%
VCIM
22
Velan Capital Investment Management
Georgia
$23.1M -$3.67M -50,666 -14%
Goldman Sachs
23
Goldman Sachs
New York
$21.5M -$16.3K -225 -0.1%
SCM
24
Soleus Capital Management
Connecticut
$18.7M -$1.15M -15,858 -6%
Alyeska Investment Group
25
Alyeska Investment Group
Illinois
$17.5M +$16.4M +226,788 New
1
2 3 4 5

PRAX Hedge Fund Activity: Q4 2024 in Review

162 of the 7,592 institutional investors tracked by Wall St. Rank reported a position in Praxis Precision Medicines (PRAX) for Q4 2024, worth a combined $1.67B — up 53% from $1.09B a quarter earlier.

Buyers outnumbered sellers: 38 funds opened new PRAX positions and 10 closed out — a net gain of 28 holders — while 56 added to existing stakes and 52 trimmed.

The largest buyer was Morgan Stanley, adding an estimated $78.4M. The largest seller was Point72 Asset Management, cutting an estimated $37M.

  • 162 institutional investors held Praxis Precision Medicines (PRAX) as of Q4 2024, up from 134 in Q3 2024.
  • Funds reported $1.67B of Praxis Precision Medicines stock for Q4 2024, up 53% quarter-over-quarter.
  • 38 funds opened new Praxis Precision Medicines positions in Q4 2024 and 10 closed out, a net change of +28 holders.
  • The largest Praxis Precision Medicines buyer in Q4 2024 was Morgan Stanley, an estimated $78.4M added.
  • The largest Praxis Precision Medicines seller in Q4 2024 was Point72 Asset Management, an estimated $37M sold.

Based on aggregated 13F filings for Q4 2024.