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Praxis Precision Medicines
PRAX

162 hedge funds and large institutions have $1.67B invested in Praxis Precision Medicines in 2024 Q4 according to their latest regulatory filings, with 38 funds opening new positions, 56 increasing their positions, 52 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

280% more first-time investments, than exits

New positions opened: 38 | Existing positions closed: 10

155% more call options, than puts

Call options by funds: $74.7M | Put options by funds: $29.3M

53% more capital invested

Capital invested by funds: $1.09B → $1.67B (+$580M)

40% more funds holding in top 10

Funds holding in top 10: 5 → 7 (+2)

21% more funds holding

Funds holding: 134 → 162 (+28)

10.29% more ownership

Funds ownership: 106.24% → 116.53% (+10%)

8% more repeat investments, than reductions

Existing positions increased: 56 | Existing positions reduced: 52

Holders
162
Holders Change
+28
Holders Change %
+20.9%
% of All Funds
2.13%
Holding in Top 10
7
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+40%
% of All Funds
0.09%
New
38
Increased
56
Reduced
52
Closed
10
Calls
$74.7M
Puts
$29.3M
Net Calls
+$45.5M
Net Calls Change
+$41.4M

Top Buyers

1
Morgan Stanley
Morgan Stanley
New York
+$78.4M
2
CAM
Cormorant Asset Management
Massachusetts
+$59.6M
3
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$39.7M
4
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$29.4M
5
VA
VR Adviser
New York
+$20.5M

Top Sellers

1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$37M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$18M
3
5VM
5AM Venture Management
California
-$12.3M
4
Wellington Management Group
Wellington Management Group
Massachusetts
-$11.3M
5
Marshall Wace
Marshall Wace
United Kingdom
-$8.09M
Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
26
Fidelity Investments
Massachusetts
$14.5M -$6.19M -85,528 -31%
5VM
27
5AM Venture Management
California
$13.1M -$12.3M -170,000 -50%
Northern Trust
28
Northern Trust
Illinois
$12.9M +$1.11M +15,323 +10%
DCM
29
Driehaus Capital Management
Illinois
$12.7M -$82.8K -1,144 -0.7%
Susquehanna International Group
30
Susquehanna International Group
Pennsylvania
$12.2M +$9.33M +128,931 +445%
Millennium Management
31
Millennium Management
New York
$11.6M +$10.6M +146,723 +3,519%
Charles Schwab
32
Charles Schwab
California
$11M +$423K +5,840 +4%
SC
33
Stempoint Capital
New York
$10.3M -$2.88M -39,856 -23%
UBS Group
34
UBS Group
Switzerland
$9.26M +$6.56M +90,717 +307%
PHS
35
PFM Health Sciences
California
$9.2M -$4.6M -63,583 -35%
Norges Bank
36
Norges Bank
Norway
$9.15M +$8.24M +113,900 +2,278%
CS
37
Candriam SCA
Luxembourg
$9.08M -$3.19M -44,061 -27%
Voloridge Investment Management
38
Voloridge Investment Management
Florida
$8.93M +$2.96M +40,875 +54%
PAMP
39
Polar Asset Management Partners
Ontario, Canada
$7.59M +$7.14M +98,617 New
Citigroup
40
Citigroup
New York
$7.31M +$846K +11,697 +14%
Citadel Advisors
41
Citadel Advisors
Florida
$7.17M +$3.27M +45,156 +94%
SFM
42
Sphera Funds Management
Israel
$7.05M -$4.39M -60,724 -40%
Walleye Capital
43
Walleye Capital
New York
$6.9M +$2.46M +34,000 +61%
Invesco
44
Invesco
Georgia
$6.69M -$1.5M -20,730 -19%
AllianceBernstein
45
AllianceBernstein
Tennessee
$6.05M +$4.38M +60,587 +336%
SCM
46
Silverarc Capital Management
Massachusetts
$5.58M +$396K +5,471 +8%
ACP
47
Acuta Capital Partners
California
$5.19M +$724K +10,000 +17%
7IH
48
72 Investment Holdings
Connecticut
$5.07M – – –
Wellington Management Group
49
Wellington Management Group
Massachusetts
$4.92M -$11.3M -155,973 -71%
Marshall Wace
50
Marshall Wace
United Kingdom
$4.49M -$8.09M -111,790 -66%
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PRAX Hedge Fund Activity: Q4 2024 in Review

162 of the 7,592 institutional investors tracked by Wall St. Rank reported a position in Praxis Precision Medicines (PRAX) for Q4 2024, worth a combined $1.67B — up 53% from $1.09B a quarter earlier.

Buyers outnumbered sellers: 38 funds opened new PRAX positions and 10 closed out — a net gain of 28 holders — while 56 added to existing stakes and 52 trimmed.

The largest buyer was Morgan Stanley, adding an estimated $78.4M. The largest seller was Point72 Asset Management, cutting an estimated $37M.

  • 162 institutional investors held Praxis Precision Medicines (PRAX) as of Q4 2024, up from 134 in Q3 2024.
  • Funds reported $1.67B of Praxis Precision Medicines stock for Q4 2024, up 53% quarter-over-quarter.
  • 38 funds opened new Praxis Precision Medicines positions in Q4 2024 and 10 closed out, a net change of +28 holders.
  • The largest Praxis Precision Medicines buyer in Q4 2024 was Morgan Stanley, an estimated $78.4M added.
  • The largest Praxis Precision Medicines seller in Q4 2024 was Point72 Asset Management, an estimated $37M sold.

Based on aggregated 13F filings for Q4 2024.