|
1
|
Avoro Capital Advisors
New York
|
$388M
|
–
|
–
|
–
|
|
|
2
|
Vanguard Group
Malvern,
Pennsylvania
|
$330M
|
+$13.3M
|
+180,278
|
+4%
|
|
|
3
|
Wellington Management Group
Boston,
Massachusetts
|
$242M
|
+$41.7M
|
+563,281
|
+19%
|
|
|
4
|
Aviva Holdings
New Providence,
Bahamas
|
$219M
|
–
|
–
|
–
|
|
|
5
|
Perceptive Advisors
New York
|
$194M
|
-$6.07M
|
-82,067
|
-3%
|
|
|
6
|
|
$170M
|
+$1.29M
|
+17,385
|
+0.7%
|
|
|
7
|
Fidelity Investments
Boston,
Massachusetts
|
$150M
|
+$9.85M
|
+133,158
|
+7%
|
|
|
8
|
Boxer Capital
San Diego,
California
|
$140M
|
–
|
–
|
–
|
|
|
9
|
Camber Capital Management
Boston,
Massachusetts
|
$140M
|
+$99.9M
|
+1,350,000
|
+208%
|
|
|
10
|
Armistice Capital
New York
|
$133M
|
-$11M
|
-148,000
|
-7%
|
|
|
11
|
|
$131M
|
–
|
–
|
–
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$110M
|
-$22.6M
|
-305,076
|
-16%
|
|
|
13
|
Ameriprise
Minneapolis,
Minnesota
|
$103M
|
+$581K
|
+7,848
|
+0.5%
|
|
|
14
|
Franklin Resources
San Mateo,
California
|
$102M
|
+$128K
|
+1,728
|
+0.1%
|
|
|
15
|
|
$99.1M
|
+$24.3M
|
+328,492
|
+30%
|
|
|
16
|
Adage Capital Partners
Boston,
Massachusetts
|
$99.1M
|
+$105M
|
+1,418,747
|
New
|
|
|
17
|
Baker Bros. Advisors
New York
|
$98.5M
|
–
|
–
|
–
|
|
|
18
|
|
$92.5M
|
+$16.6M
|
+225,000
|
+20%
|
|
|
19
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$79.8M
|
+$6.75M
|
+91,225
|
+9%
|
|
|
20
|
EcoR1 Capital
San Francisco,
California
|
$70.9M
|
+$75.1M
|
+1,015,572
|
New
|
|
|
21
|
|
$68.9M
|
+$6.05M
|
+81,721
|
+9%
|
|
|
22
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$60.5M
|
+$1.61M
|
+21,799
|
+3%
|
|
|
23
|
Paradigm Biocapital Advisors
New York
|
$59.4M
|
+$14.1M
|
+190,417
|
+29%
|
|
|
24
|
Janus Henderson Group
London,
|
$50.7M
|
-$418K
|
-5,649
|
-0.8%
|
|
|
25
|
Candriam SCA
Strassen, Luxembourg,
Luxembourg
|
$46.3M
|
+$5.05M
|
+68,217
|
+11%
|
|
