|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$338M
|
+$164M
|
+2,409,882
|
+110%
|
|
|
2
|
Avoro Capital Advisors
New York
|
$283M
|
-$63.6M
|
-935,601
|
-19%
|
|
|
3
|
Aviva Holdings
New Providence,
Bahamas
|
$230M
|
–
|
–
|
–
|
|
|
4
|
Baker Bros. Advisors
New York
|
$184M
|
–
|
–
|
–
|
|
|
5
|
|
$171M
|
+$19.3M
|
+283,146
|
+14%
|
|
|
6
|
Vanguard Group
Malvern,
Pennsylvania
|
$160M
|
+$51M
|
+750,022
|
+52%
|
|
|
7
|
Janus Henderson Group
London,
|
$149M
|
+$65M
|
+956,022
|
+89%
|
|
|
8
|
Boxer Capital
San Diego,
California
|
$126M
|
+$10.2M
|
+150,000
|
+10%
|
|
|
9
|
State Street
Boston,
Massachusetts
|
$104M
|
-$8.13M
|
-119,510
|
-8%
|
|
|
10
|
Farallon Capital Management
San Francisco,
California
|
$88M
|
-$6.8M
|
-100,000
|
-8%
|
|
|
11
|
Jennison Associates
New York
|
$87.4M
|
-$1.62M
|
-23,785
|
-2%
|
|
|
12
|
Perceptive Advisors
New York
|
$85.3M
|
+$70.6M
|
+1,038,507
|
+825%
|
|
|
13
|
Cormorant Asset Management
Boston,
Massachusetts
|
$78.8M
|
-$46M
|
-676,699
|
-39%
|
|
|
14
|
EcoR1 Capital
San Francisco,
California
|
$73.3M
|
+$24M
|
+352,831
|
+55%
|
|
|
15
|
OppenheimerFunds
New York
|
$60.1M
|
+$214K
|
+3,146
|
+0.4%
|
|
|
16
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$59.9M
|
+$33.2M
|
+488,468
|
+148%
|
|
|
17
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
$46.2M
|
+$24.8M
|
+364,005
|
+137%
|
|
|
18
|
Franklin Resources
San Mateo,
California
|
$32.6M
|
+$30.3M
|
+445,151
|
New
|
|
|
19
|
BVF Inc
San Francisco,
California
|
$31.6M
|
-$17.5M
|
-257,151
|
-37%
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$27.2M
|
+$3.91M
|
+57,485
|
+18%
|
|
|
21
|
Wells Fargo
San Francisco,
California
|
$25.3M
|
-$510K
|
-7,491
|
-2%
|
|
|
22
|
|
$22.9M
|
+$18.6M
|
+273,328
|
+705%
|
|
|
23
|
|
$22.4M
|
+$15.5M
|
+228,312
|
+295%
|
|
|
24
|
Northern Trust
Chicago,
Illinois
|
$21.4M
|
+$1.2M
|
+17,591
|
+6%
|
|
|
25
|
Credit Suisse
Zurich,
Switzerland
|
$20.5M
|
-$12.2M
|
-179,663
|
-39%
|
|
