|
1
|
Avoro Capital Advisors
New York
|
$398M
|
–
|
–
|
–
|
|
|
2
|
Aviva Holdings
New Providence,
Bahamas
|
$323M
|
–
|
–
|
–
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$307M
|
+$62.5M
|
+802,468
|
+37%
|
|
|
4
|
Fidelity Investments
Boston,
Massachusetts
|
$302M
|
-$131M
|
-1,677,339
|
-36%
|
|
|
5
|
Perceptive Advisors
New York
|
$299M
|
+$135M
|
+1,735,224
|
+149%
|
|
|
6
|
|
$261M
|
+$15.6M
|
+199,939
|
+9%
|
|
|
7
|
Baker Bros. Advisors
New York
|
$259M
|
–
|
–
|
–
|
|
|
8
|
Boxer Capital
San Diego,
California
|
$177M
|
–
|
–
|
–
|
|
|
9
|
Janus Henderson Group
London,
|
$173M
|
-$27.8M
|
-357,205
|
-18%
|
|
|
10
|
Sands Capital Management
Arlington,
Virginia
|
$142M
|
+$107M
|
+1,379,614
|
New
|
|
|
11
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$124M
|
+$30.2M
|
+388,516
|
+48%
|
|
|
12
|
State Street
Boston,
Massachusetts
|
$118M
|
-$21M
|
-269,916
|
-19%
|
|
|
13
|
Cormorant Asset Management
Boston,
Massachusetts
|
$113M
|
+$1.95M
|
+25,000
|
+2%
|
|
|
14
|
|
$103M
|
+$59.9M
|
+769,429
|
+330%
|
|
|
15
|
Farallon Capital Management
San Francisco,
California
|
$102M
|
-$16M
|
-205,000
|
-17%
|
|
|
16
|
Jennison Associates
New York
|
$99.6M
|
-$17.5M
|
-225,348
|
-19%
|
|
|
17
|
EcoR1 Capital
San Francisco,
California
|
$61.6M
|
-$31.3M
|
-402,289
|
-40%
|
|
|
18
|
BVF Inc
San Francisco,
California
|
$54.3M
|
+$7.44M
|
+95,553
|
+22%
|
|
|
19
|
Renaissance Technologies
New York
|
$46.2M
|
+$31M
|
+398,700
|
+793%
|
|
|
20
|
Geode Capital Management
Boston,
Massachusetts
|
$42.5M
|
+$3.2M
|
+41,098
|
+11%
|
|
|
21
|
Point72 Asset Management
Stamford,
Connecticut
|
$42.1M
|
+$30.5M
|
+391,735
|
+2,278%
|
|
|
22
|
Lord, Abbett & Co
Jersey City,
New Jersey
|
$38.8M
|
-$19.8M
|
-253,693
|
-40%
|
|
|
23
|
Ghost Tree Capital
New York
|
$34.5M
|
+$14.4M
|
+185,000
|
+123%
|
|
|
24
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$33.2M
|
+$19.5M
|
+250,442
|
+349%
|
|
|
25
|
Great Point Partners
Greenwich,
Connecticut
|
$30.9M
|
+$23.4M
|
+300,000
|
New
|
|
