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LYRA

LYRA THERAPEUTICS INC
LYRA

Delisted

LYRA was delisted on the 16th of March, 2026.

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57 hedge funds and large institutions have $3.23M invested in LYRA THERAPEUTICS INC in 2025 Q1 according to their latest regulatory filings, with 6 funds opening new positions, 13 increasing their positions, 19 reducing their positions, and 3 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more first-time investments, than exits

New positions opened: 6 | Existing positions closed: 3

75% more call options, than puts

Call options by funds: $7K | Put options by funds: $4K

6% more funds holding

Funds holding: 54 → 57 (+3)

0.04% less ownership

Funds ownership: 0.82% → 0.78% (-0.04%)

32% less repeat investments, than reductions

Existing positions increased: 13 | Existing positions reduced: 19

42% less capital invested

Capital invested by funds: $5.54M → $3.23M (-$2.32M)

Holders
57
Holders Change
+3
Holders Change %
+5.56%
% of All Funds
0.76%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
6
Increased
13
Reduced
19
Closed
3
Calls
$7K
Puts
$4K
Net Calls
+$3K
Net Calls Change
-$1K

Top Buyers

Rank Fund Capital Flow
1
Geode Capital Management
Geode Capital Management
Massachusetts
+$24.3K
2
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$21.3K
3
RhumbLine Advisers
RhumbLine Advisers
Massachusetts
+$8.69K
4
Northern Trust
Northern Trust
Illinois
+$8.67K
5
Jane Street
Jane Street
New York
+$8.23K

Top Sellers

Rank Fund Capital Flow
1
SB
Samsara BioCapital
California
-$108K
2
Qube Research & Technologies (QRT)
Qube Research & Technologies (QRT)
United Kingdom
-$70.6K
3
Goldman Sachs
Goldman Sachs
New York
-$34.7K
4
Morgan Stanley
Morgan Stanley
New York
-$28.2K
5
JP Morgan Chase
JP Morgan Chase
New York
-$18.7K
Name Holding Trade Value Shares
Change 		Change in
Stake
Barclays
26
Barclays
United Kingdom
$6.32K -$4.71K -504 -33%
Jane Street
27
Jane Street
New York
$5.56K +$8.23K +880 New
Citigroup
28
Citigroup
New York
$4.44K -$542 -58 -8%
AllianceBernstein
29
AllianceBernstein
Tennessee
$4.18K – – –
SEI Investments
30
SEI Investments
Pennsylvania
$3.83K -$10.1K -1,081 -64%
Mirae Asset Global ETFs Holdings
31
Mirae Asset Global ETFs Holdings
Hong Kong
$3.67K +$234 +25 +5%
Wells Fargo
32
Wells Fargo
California
$3.2K +$103 +11 +2%
T. Rowe Price Associates
33
T. Rowe Price Associates
Maryland
$3K – – –
CF
34
Corebridge Financial
Texas
$2.99K -$65 -7 -1%
Invesco
35
Invesco
Georgia
$2.98K – – –
Bank of America
36
Bank of America
North Carolina
$2.69K -$5.86K -626 -59%
IIM
37
INTECH Investment Management
Florida
$2.09K +$3.1K +331 New
SG Americas Securities
38
SG Americas Securities
New York
$2K -$3.24K -346 -54%
Squarepoint
39
Squarepoint
New York
$1.93K +$2.86K +306 New
AHL
40
Abel Hall LLC
Louisiana
$1.54K -$1.02K -109 -31%
CWM
41
CIBC World Markets
New York
$1.36K +$2.01K +215 New
ProShare Advisors
42
ProShare Advisors
Maryland
$1.32K -$589 -63 -23%
SCA
43
Sassicaia Capital Advisers
New York
$1.26K +$1.87K +200 New
Carson Wealth (CWM LLC)
44
Carson Wealth (CWM LLC)
Nebraska
$1K +$253 +27 +25%
Royal Bank of Canada
45
Royal Bank of Canada
Ontario, Canada
$1K +$505 +54 +51%
Northwestern Mutual Wealth Management
46
Northwestern Mutual Wealth Management
Wisconsin
$758 +$1.12K +120 New
AIP
47
Ameritas Investment Partners
Nebraska
$599 – – –
SS
48
SBI Securities
Japan
$540 – – –
California State Teachers Retirement System (CalSTRS)
49
California State Teachers Retirement System (CalSTRS)
California
$443 – – –
Comerica Bank
50
Comerica Bank
Texas
$146 – – –
1
2
3

LYRA Hedge Fund Activity: Q1 2025 in Review

57 of the 7,460 institutional investors tracked by Wall St. Rank reported a position in LYRA THERAPEUTICS INC (LYRA) for Q1 2025, worth a combined $3.23M — down 42% from $5.54M a quarter earlier.

Buyers outnumbered sellers: 6 funds opened new LYRA positions and 3 closed out — a net gain of 3 holders — while 13 added to existing stakes and 19 trimmed.

The largest buyer was Geode Capital Management, adding an estimated $24.3K. The largest seller was Samsara BioCapital, cutting an estimated $108K.

  • 57 institutional investors held LYRA THERAPEUTICS INC (LYRA) as of Q1 2025, up from 54 in Q4 2024.
  • Funds reported $3.23M of LYRA THERAPEUTICS INC stock for Q1 2025, down 42% quarter-over-quarter.
  • 6 funds opened new LYRA THERAPEUTICS INC positions in Q1 2025 and 3 closed out, a net change of +3 holders.
  • The largest LYRA THERAPEUTICS INC buyer in Q1 2025 was Geode Capital Management, an estimated $24.3K added.
  • The largest LYRA THERAPEUTICS INC seller in Q1 2025 was Samsara BioCapital, an estimated $108K sold.

Based on aggregated 13F filings for Q1 2025.